A pan-cancer analysis of Wnt family member 7B in human cancers

Cancer Innovation Pub Date : 2024-09-09 DOI:10.1002/cai2.139

Rui Wang, Ni-sha Wu, Li Wang, Zhi-zhao Zhang, Cheng-fang Wang, Yan Wang, Yan Liang, Yi Zhang, Xiao-wei Qi

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Abstract

Background

Previous studies have highlighted the crucial role of Wnt7B in the development of various cancers, including breast, pancreatic, and gastric cancers. However, research into the involvement of Wnt7B is often confined to specific tumor types, with a noticeable lack of comprehensive studies spanning multiple cancer forms. The potential of Wnt7B as a diagnostic or prognostic cancer biomarker has not been fully explored.

Methods

In this study, we combined bioinformatics and immunohistochemistry analyses to examine the expression patterns and functions of Wnt7B in cancerous and adjacent noncancerous tissues across a range of tumors.

Results

Our data indicate that Wnt7B may serve as a novel prognostic biomarker and therapeutic target in certain cancers.

Conclusion

We found significant upregulation of Wnt7B expression levels in the majority of cancer cases examined. Furthermore, Wnt7B can influence cancer prognosis by modulating the tumor microenvironment, immune cell infiltration, and tumor stemness, among other factors. Additionally, we examined the associations between anticancer drug sensitivity and Wnt7B expression, which could aid in the development of more precise clinical therapies.

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对人类癌症中 Wnt 家族成员 7B 的泛癌症分析

背景以前的研究强调了 Wnt7B 在乳腺癌、胰腺癌和胃癌等各种癌症的发展过程中的关键作用。然而，有关 Wnt7B 参与作用的研究往往局限于特定的肿瘤类型，明显缺乏横跨多种癌症类型的综合性研究。Wnt7B作为癌症诊断或预后生物标志物的潜力尚未得到充分挖掘。方法在本研究中，我们结合生物信息学和免疫组化分析，研究了 Wnt7B 在多种肿瘤的癌组织和邻近非癌组织中的表达模式和功能。结果我们的数据表明，Wnt7B 可作为某些癌症的新型预后生物标志物和治疗靶点。结论我们发现在大多数癌症病例中，Wnt7B 的表达水平明显上调。此外，Wnt7B 可通过调节肿瘤微环境、免疫细胞浸润和肿瘤干性等因素影响癌症预后。此外，我们还研究了抗癌药物敏感性与 Wnt7B 表达之间的关联，这有助于开发更精确的临床疗法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Innovation

CiteScore

0.70

自引率

0.00%

发文量