Assessing clonal changes in T cells over time following immunotherapy is a breeze with Cyclone

IF 48.8 1区医学 Q1 CELL BIOLOGY

Cancer Cell Pub Date : 2024-09-09 DOI:10.1016/j.ccell.2024.08.014

Anthony R. Cillo, John M. Kirkwood

引用次数: 0

Abstract

Combination immunotherapy improves outcomes in metastatic melanoma, but the underlying mechanisms remain unclear. In this issue of Cancer Cell, Wang et al.¹ report dynamics and transcriptional states of CD8⁺ T cell clones over time in patients treated with anti-PD-1, anti-CTLA-4, or a combination of the two. These findings have important implications for understanding and monitoring combination immunotherapy.

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使用 Cyclone 可轻松评估免疫疗法后 T 细胞随时间发生的克隆变化

联合免疫疗法能改善转移性黑色素瘤的治疗效果，但其潜在机制仍不清楚。在本期《癌细胞》（Cancer Cell）杂志上，Wang等人1报告了接受抗PD-1、抗CTLA-4或两者联合治疗的患者CD8+T细胞克隆的动态和转录状态。这些发现对理解和监测联合免疫疗法具有重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Cell 医学-肿瘤学

CiteScore

55.20

自引率

1.20%

发文量

179

审稿时长

4-8 weeks

期刊介绍： Cancer Cell is a journal that focuses on promoting major advances in cancer research and oncology. The primary criteria for considering manuscripts are as follows: Major advances: Manuscripts should provide significant advancements in answering important questions related to naturally occurring cancers. Translational research: The journal welcomes translational research, which involves the application of basic scientific findings to human health and clinical practice. Clinical investigations: Cancer Cell is interested in publishing clinical investigations that contribute to establishing new paradigms in the treatment, diagnosis, or prevention of cancers. Insights into cancer biology: The journal values clinical investigations that provide important insights into cancer biology beyond what has been revealed by preclinical studies. Mechanism-based proof-of-principle studies: Cancer Cell encourages the publication of mechanism-based proof-of-principle clinical studies, which demonstrate the feasibility of a specific therapeutic approach or diagnostic test.