Classifying cancer-associated fibroblasts—The good, the bad, and the target

IF 48.8 1区医学 Q1 CELL BIOLOGY

Cancer Cell Pub Date : 2024-09-09 DOI:10.1016/j.ccell.2024.08.011

Lena Cords, Natalie de Souza, Bernd Bodenmiller

引用次数: 0

Abstract

Cancer-associated fibroblasts (CAFs) are heterogeneous and ubiquitous stromal cells within the tumor microenvironment (TME). Numerous CAF types have been described, typically using single-cell technologies such as single-cell RNA sequencing. There is no general classification system for CAFs, hampering their study and therapeutic targeting. We propose a simple CAF classification system based on single-cell phenotypes and spatial locations of CAFs in multiple cancer types, assess how our scheme fits within current knowledge, and invite the CAF research community to further refine it.

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癌症相关成纤维细胞的分类--好的、坏的和目标

癌症相关成纤维细胞（CAFs）是肿瘤微环境（TME）中异质性的、无处不在的基质细胞。人们通常利用单细胞技术（如单细胞 RNA 测序）描述了许多 CAF 类型。目前还没有CAF的通用分类系统，这阻碍了对它们的研究和靶向治疗。我们根据多种癌症类型中 CAF 的单细胞表型和空间位置提出了一个简单的 CAF 分类系统，评估了我们的方案与现有知识的契合程度，并邀请 CAF 研究界进一步完善该系统。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Cell 医学-肿瘤学

CiteScore

55.20

自引率

1.20%

发文量

179

审稿时长

4-8 weeks

期刊介绍： Cancer Cell is a journal that focuses on promoting major advances in cancer research and oncology. The primary criteria for considering manuscripts are as follows: Major advances: Manuscripts should provide significant advancements in answering important questions related to naturally occurring cancers. Translational research: The journal welcomes translational research, which involves the application of basic scientific findings to human health and clinical practice. Clinical investigations: Cancer Cell is interested in publishing clinical investigations that contribute to establishing new paradigms in the treatment, diagnosis, or prevention of cancers. Insights into cancer biology: The journal values clinical investigations that provide important insights into cancer biology beyond what has been revealed by preclinical studies. Mechanism-based proof-of-principle studies: Cancer Cell encourages the publication of mechanism-based proof-of-principle clinical studies, which demonstrate the feasibility of a specific therapeutic approach or diagnostic test.