Epigenetic reprogramming enables NF1A/B oncogenic role in SHH medulloblastoma

IF 10.7 1区生物学 Q1 CELL BIOLOGY

Developmental cell Pub Date : 2024-09-09 DOI:10.1016/j.devcel.2024.07.002

Sara Badodi, Silvia Marino

引用次数: 0

Abstract

In this issue of Developmental Cell, Shiraishi et al. investigate the epigenetic changes occurring during the formation of SHH medulloblastoma and show that an epigenomic shift renders Nuclear Factor I family of transcription factors oncogenic.

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表观遗传学重编程使 NF1A/B 在 SHH 髓母细胞瘤中发挥致癌作用

在本期《发育细胞》（Developmental Cell）杂志上，Shiraishi 等人研究了 SHH 髓母细胞瘤形成过程中发生的表观遗传学变化，结果表明，表观遗传学变化使核因子 I 家族转录因子具有致癌性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Developmental cell 生物-发育生物学

CiteScore

18.90

自引率

1.70%

发文量

203

审稿时长

3-6 weeks

期刊介绍： Developmental Cell, established in 2001, is a comprehensive journal that explores a wide range of topics in cell and developmental biology. Our publication encompasses work across various disciplines within biology, with a particular emphasis on investigating the intersections between cell biology, developmental biology, and other related fields. Our primary objective is to present research conducted through a cell biological perspective, addressing the essential mechanisms governing cell function, cellular interactions, and responses to the environment. Moreover, we focus on understanding the collective behavior of cells, culminating in the formation of tissues, organs, and whole organisms, while also investigating the consequences of any malfunctions in these intricate processes.

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