Fabrication of fMW@TiO2@MoS2-Sm2S3/GCE electrochemical nanosensor for simultaneous measurement of sertraline and buspirone neuroleptic drugs

IF 5.7 2区材料科学 Q2 CHEMISTRY, PHYSICAL

Surfaces and Interfaces Pub Date : 2024-09-05 DOI:10.1016/j.surfin.2024.105063

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Abstract

In this paper for the first time, due to the importance of simultaneous administration of sertraline (SRT) and buspirone (BPH), a sensitive electrochemical nanosensor was fabricated and used for simultaneous measurement of them. Firstly, fMW@TiO₂@MoS₂-Sm₂S₃ was synthesized and characterized by different techniques. The performance of fMW@TiO₂@MoS₂-Sm₂S₃/GCE nanocomposite was investigated for simultaneous quantifications of SRT and BPH using different electrochemical methods. Response surface methodology (RSM) indicated that pH 7.0 for phosphate buffer solutions (PBS), scan rate of 0.08 V s^-1, accumulation potential of 0.4 V and accumulation time of 125 s in CHA get maximum anodic currents. The anodic peak current densities of SRT and BPH drugs were improved excellently on the surface of fMW@TiO₂@MoS₂-Sm₂S₃/GCE compared to bare GCE. With the DPV method, the linear response 1.53–38.46, 38.46–74.07 µM and 1.11–29.12, 29.12–90.90 µM were obtained for SRT and BPH, respectively. Also, the detection limit of 0.50 µM and 0.36 µM were acquired for SRT and BPH, respectively. The catalytic rate constants were calculated to be 3.63 × 10⁷ and 2.80 × 10⁷ cm³ mol^-1 s^-1 for SRT and BPH, respectively. The practical application of the fMW@TiO₂@MoS₂-Sm₂S₃ for measurements of the SRT and BPH in human plasma and tablets showed good recovery percentage.

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用于同时测量舍曲林和丁螺环酮神经安定药物的 fMW@TiO2@MoS2-Sm2S3/GCE 电化学纳米传感器的制备方法

鉴于同时服用舍曲林（SRT）和丁螺环酮（BPH）的重要性，本文首次制作了一种灵敏的电化学纳米传感器，用于同时测量这两种药物。首先合成了 fMW@TiO2@MoS2-Sm2S3，并通过不同的技术对其进行了表征。采用不同的电化学方法研究了 fMW@TiO2@MoS2-Sm2S3/GCE 纳米复合材料同时定量 SRT 和 BPH 的性能。响应面方法学（RSM）表明，磷酸盐缓冲溶液（PBS）的 pH 值为 7.0、扫描速率为 0.08 V s-1、累积电位为 0.4 V、CHA 中的累积时间为 125 s 可获得最大阳极电流。与裸 GCE 相比，fMW@TiO2@MoS2-Sm2S3/GCE 表面 SRT 和 BPH 药物的阳极峰值电流密度得到了很好的改善。采用 DPV 方法，SRT 和 BPH 的线性响应分别为 1.53-38.46、38.46-74.07 µM 和 1.11-29.12、29.12-90.90 µM。此外，SRT 和 BPH 的检测限分别为 0.50 µM 和 0.36 µM。经计算，SRT 和 BPH 的催化速率常数分别为 3.63 × 107 和 2.80 × 107 cm3 mol-1 s-1。将 fMW@TiO2@MoS2-Sm2S3 实际应用于人体血浆和药片中 SRT 和 BPH 的测量，显示出良好的回收率。

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来源期刊

Surfaces and Interfaces Chemistry-General Chemistry

CiteScore

8.50

自引率

6.50%

发文量

753

审稿时长

35 days

期刊介绍： The aim of the journal is to provide a respectful outlet for ''sound science'' papers in all research areas on surfaces and interfaces. We define sound science papers as papers that describe new and well-executed research, but that do not necessarily provide brand new insights or are merely a description of research results. Surfaces and Interfaces publishes research papers in all fields of surface science which may not always find the right home on first submission to our Elsevier sister journals (Applied Surface, Surface and Coatings Technology, Thin Solid Films)