A Comprehensive Consolidation of Data on the Relationship Between Surfactant Protein-B (SFTPB) Polymorphisms and Susceptibility to Bronchopulmonary Dysplasia.

IF 0.7 4区医学 Q4 PATHOLOGY

Fetal and Pediatric Pathology Pub Date : 2024-11-01 Epub Date: 2024-09-08 DOI:10.1080/15513815.2024.2400145

Reza Bahrami, Mohammad Golshan-Tafti, Seyed Alireza Dastgheib, Kamran Alijanpour, Maryam Yeganegi, Mohamad Hosein Lookzadeh, Seyed Reza Mirjalili, Sepideh Azizi, Maryam Aghasipour, Amirmasoud Shiri, Mahmood Noorishadkam, Hossein Neamatzadeh

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引用次数: 0

Abstract

Background: This meta-analysis aims to evaluate the potential link between common variations in the Surfactant Protein-B (SFTPB) gene and the risk of bronchopulmonary dysplasia (BPD) in preterm neonates.

Methods: All pertinent articles published prior to February 1, 2024, in PubMed, Web of Science, EMBASE, CNKI, and Scopus databases were reviewed.

Results: Nineteen case-control studies involving 1149 BPD cases and 1845 non-BPD controls, were analyzed. Combined data indicated a significant link between SFTPB -18 A > C and Intron 4 VNTR polymorphisms with increased BPD susceptibility, while the 1580 C > T polymorphism provides a protective impact on BPD initiation.

Conclusions: Pooled data indicated a significant association between SFTPB -18 A > C and Intron 4 VNTR polymorphisms with increased BPD risk, whereas the 1580 C > T polymorphism confers protection. These findings suggest a genetic susceptibility to BPD, underscoring the complex interplay of different genetic elements in its development.

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关于表面活性蛋白-B（SFTPB）多态性与支气管肺发育不良易感性之间关系的综合数据。

背景：这项荟萃分析旨在评估早产新生儿表面活性蛋白-B（SFTPB）基因常见变异与支气管肺发育不良（BPD）风险之间的潜在联系：方法：对 2024 年 2 月 1 日之前发表在 PubMed、Web of Science、EMBASE、CNKI 和 Scopus 数据库中的所有相关文章进行了回顾：分析了19项病例对照研究，涉及1149例BPD病例和1845例非BPD对照病例。综合数据显示，SFTPB -18 A > C 和 Intron 4 VNTR 多态性与 BPD 易感性增加有显著联系，而 1580 C > T 多态性对 BPD 的发生有保护作用：汇总数据显示，SFTPB -18 A > C 和 Intron 4 VNTR 多态性与 BPD 风险增加有明显关联，而 1580 C > T 多态性则具有保护作用。这些研究结果表明，BPD具有遗传易感性，强调了不同遗传因素在其发展过程中的复杂相互作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Fetal and Pediatric Pathology 医学-病理学

CiteScore

3.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Fetal and Pediatric Pathology is an established bimonthly international journal that publishes data on diseases of the developing embryo, newborns, children, and adolescents. The journal publishes original and review articles and reportable case reports. The expanded scope of the journal encompasses molecular basis of genetic disorders; molecular basis of diseases that lead to implantation failures; molecular basis of abnormal placentation; placentology and molecular basis of habitual abortion; intrauterine development and molecular basis of embryonic death; pathogenisis and etiologic factors involved in sudden infant death syndrome; the underlying molecular basis, and pathogenesis of diseases that lead to morbidity and mortality in newborns; prenatal, perinatal, and pediatric diseases and molecular basis of diseases of childhood including solid tumors and tumors of the hematopoietic system; and experimental and molecular pathology.