Shigella and ETEC have replaced rotavirus as main causes of childhood diarrhea in Rwanda after ten years of rotavirus vaccination.

IF 5 2区医学 Q2 IMMUNOLOGY

Journal of Infectious Diseases Pub Date : 2024-09-09 DOI:10.1093/infdis/jiae446

Jean Bosco Munyemana, Jean Claude Kabayiza, Staffan Nilsson, Maria E Andersson, Magnus Lindh

引用次数: 0

Abstract

The causes of diarrhea after ten years of rotavirus vaccination in Rwanda were investigated in 496 children with and 298 without diarrhea using a real-time PCR. Rotavirus was detected in 11% of children with diarrhea (OR 2.48, P=0.002). Comparison of population attributable fractions (PAF) show that Shigella (PAF=11%) and ETEC-eltB (PAF=12%) have replaced rotavirus as the main causative agents. The PAF for rotavirus had declined from 41% pre-vaccination to 6.5%, indicating that rotavirus has become one among several similarly important causes of childhood diarrhea in Rwanda. A rotavirus genotype shift to G3P[8] points at the importance of continued genotype surveillance.

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在卢旺达，轮状病毒疫苗接种十年后，志贺氏菌和 ETEC 已取代轮状病毒成为儿童腹泻的主要病因。

在卢旺达接种轮状病毒疫苗十年后，我们使用实时 PCR 对 496 名腹泻儿童和 298 名未腹泻儿童的腹泻原因进行了调查。在 11% 的腹泻儿童中检测到了轮状病毒（OR 2.48，P=0.002）。人群归因分数（PAF）比较显示，志贺氏菌（PAF=11%）和 ETEC-eltB（PAF=12%）已取代轮状病毒成为主要致病菌。轮状病毒的PAF从接种疫苗前的41%下降到6.5%，表明轮状病毒已成为卢旺达儿童腹泻的几个同样重要的病因之一。轮状病毒基因型转变为 G3P[8]，这说明了持续监测基因型的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Infectious Diseases 医学-传染病学

CiteScore

13.50

自引率

3.10%

发文量

449

审稿时长

2-4 weeks

期刊介绍： Published continuously since 1904, The Journal of Infectious Diseases (JID) is the premier global journal for original research on infectious diseases. The editors welcome Major Articles and Brief Reports describing research results on microbiology, immunology, epidemiology, and related disciplines, on the pathogenesis, diagnosis, and treatment of infectious diseases; on the microbes that cause them; and on disorders of host immune responses. JID is an official publication of the Infectious Diseases Society of America.