Mechanism of Zuogui pill enhancing ovarian function and skin elastic repair in premature aging rats based on artificial intelligence medical image analysis.

IF 2 4区医学 Q3 DERMATOLOGY

Skin Research and Technology Pub Date : 2024-09-01 DOI:10.1111/srt.70050

Xinpei Zhang, Fuju Wang, Xiaodan Zhu, Lan Xu, Ling Qin, Wenjuan Xu, Bozhen Fan

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Abstract

Background: AI medical image analysis shows potential applications in research on premature aging and skin. The purpose of this study was to explore the mechanism of the Zuogui pill based on artificial intelligence medical image analysis on ovarian function enhancement and skin elasticity repair in rats with premature aging.

Materials and methods: The premature aging rat model was established by using an experimental animal model. Then Zuogui pills were injected into the rats with premature aging, and the images were detected by an optical microscope. Then, through the analysis of artificial intelligence medical images, the image data is analyzed to evaluate the indicators of ovarian function.

Results: Through optical microscope image detection, we observed that the Zuogui pill played an active role in repairing ovarian tissue structure and increasing the number of follicles in mice, and Zuogui pill also significantly increased the level of progesterone in the blood of mice.

Conclusion: Most of the ZGP-induced outcomes are significantly dose-dependent.

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基于人工智能医学图像分析的左归丸增强早衰大鼠卵巢功能和皮肤弹性修复的机制

背景：人工智能医学图像分析在早衰和皮肤研究中具有潜在的应用前景。本研究旨在探讨基于人工智能医学图像分析的左归丸对早衰大鼠卵巢功能增强和皮肤弹性修复的作用机制：材料：采用实验动物模型建立早衰大鼠模型。材料：利用实验动物模型建立早衰大鼠模型，将左归丸注射到早衰大鼠体内，用光学显微镜检测图像。然后，通过人工智能医学图像分析，对图像数据进行分析，评估卵巢功能指标：通过光学显微镜图像检测，我们观察到左归丸在修复小鼠卵巢组织结构、增加卵泡数量方面发挥了积极作用，左归丸还能显著提高小鼠血液中孕酮的水平：结论：大多数左归丸诱导的结果具有明显的剂量依赖性。

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来源期刊

Skin Research and Technology 医学-皮肤病学

CiteScore

3.30

自引率

9.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Skin Research and Technology is a clinically-oriented journal on biophysical methods and imaging techniques and how they are used in dermatology, cosmetology and plastic surgery for noninvasive quantification of skin structure and functions. Papers are invited on the development and validation of methods and their application in the characterization of diseased, abnormal and normal skin. Topics include blood flow, colorimetry, thermography, evaporimetry, epidermal humidity, desquamation, profilometry, skin mechanics, epiluminiscence microscopy, high-frequency ultrasonography, confocal microscopy, digital imaging, image analysis and computerized evaluation and magnetic resonance. Noninvasive biochemical methods (such as lipids, keratin and tissue water) and the instrumental evaluation of cytological and histological samples are also covered. The journal has a wide scope and aims to link scientists, clinical researchers and technicians through original articles, communications, editorials and commentaries, letters, reviews, announcements and news. Contributions should be clear, experimentally sound and novel.

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