Prevalence of Bordetella pertussis among children aged 4 years and above presenting with acute respiratory tract infection: a cross-sectional study.

IF 4.9 4区 医学 Q1 PARASITOLOGY
Ainun Nadzurah Binti Md Bahar, Anis Najwa Muhamad, Cindy Shuan Ju Teh, Mohamad Shafiq Adnan, Shah Adam, Shih Ying Hng, Kah Peng Eg, Anna Marie Nathan
{"title":"Prevalence of <i>Bordetella pertussis</i> among children aged 4 years and above presenting with acute respiratory tract infection: a cross-sectional study.","authors":"Ainun Nadzurah Binti Md Bahar, Anis Najwa Muhamad, Cindy Shuan Ju Teh, Mohamad Shafiq Adnan, Shah Adam, Shih Ying Hng, Kah Peng Eg, Anna Marie Nathan","doi":"10.1080/20477724.2024.2400412","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction and aim: </strong>In Malaysia, pertussis in children beyond infancy is underreported. This study aimed to determine the prevalence of <i>Bordetella pertussis</i> and the prevalence of pertussis-susceptible children aged ≥4 years who presented with acute respiratory infections.</p><p><strong>Methods: </strong>This single-center, cross-sectional study conducted at the Paediatric Emergency Department from 1 October 2022, to 31 January 2023, included children aged 4 years and older with ARTIs symptoms and excluded those who were COVID-19 positive. <i>B. pertussis</i> was detected via quantitative Polymerase Chain Reaction on nasopharyngeal swabs and pertussis toxin (PT) IgG enzyme-linked immunosorbent assay.</p><p><strong>Results: </strong>Children (<i>n</i> = 298) with a median (Interquartile range, [IQR]) age of 6.0 (5.0, 8.0) years old were recruited, and 98% were vaccinated adequately. Two cases of <i>B. pertussis</i> (<i>n</i> = 2/298, 0.67%) were detected. Both children were also co-infected with <i>Bordetella spp</i>. The majority of the patients (<i>n</i> = 246/296, 83.1%) had low protective antibodies against pertussis (anti-PT IgG <5 IU/ml), and children 5 years and older were more likely to have lower anti-PT Ig G levels of <5 IU/ml (odds ratio 2.02 [95% CI 1.04,3.90]) compared to children 4 years old.</p><p><strong>Conclusion: </strong>The prevalence of pertussis was low. However, there is significant waning immunity. Booster doses of pertussis vaccine should be given to all school-aged children.</p>","PeriodicalId":19850,"journal":{"name":"Pathogens and Global Health","volume":" ","pages":"1-5"},"PeriodicalIF":4.9000,"publicationDate":"2024-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pathogens and Global Health","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/20477724.2024.2400412","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PARASITOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Introduction and aim: In Malaysia, pertussis in children beyond infancy is underreported. This study aimed to determine the prevalence of Bordetella pertussis and the prevalence of pertussis-susceptible children aged ≥4 years who presented with acute respiratory infections.

Methods: This single-center, cross-sectional study conducted at the Paediatric Emergency Department from 1 October 2022, to 31 January 2023, included children aged 4 years and older with ARTIs symptoms and excluded those who were COVID-19 positive. B. pertussis was detected via quantitative Polymerase Chain Reaction on nasopharyngeal swabs and pertussis toxin (PT) IgG enzyme-linked immunosorbent assay.

Results: Children (n = 298) with a median (Interquartile range, [IQR]) age of 6.0 (5.0, 8.0) years old were recruited, and 98% were vaccinated adequately. Two cases of B. pertussis (n = 2/298, 0.67%) were detected. Both children were also co-infected with Bordetella spp. The majority of the patients (n = 246/296, 83.1%) had low protective antibodies against pertussis (anti-PT IgG <5 IU/ml), and children 5 years and older were more likely to have lower anti-PT Ig G levels of <5 IU/ml (odds ratio 2.02 [95% CI 1.04,3.90]) compared to children 4 years old.

Conclusion: The prevalence of pertussis was low. However, there is significant waning immunity. Booster doses of pertussis vaccine should be given to all school-aged children.

一项横断面研究:4 岁及以上急性呼吸道感染儿童的百日咳博德特氏菌感染率。
导言和目的:在马来西亚,婴儿期以后儿童的百日咳发病率较低。本研究旨在确定百日咳博德特氏菌的流行率以及急性呼吸道感染的≥4岁百日咳易感儿童的流行率:这项单中心横断面研究于 2022 年 10 月 1 日至 2023 年 1 月 31 日在儿科急诊室进行,研究对象包括有急性呼吸道感染症状的 4 岁及以上儿童,不包括 COVID-19 阳性的儿童。通过鼻咽拭子上的定量聚合酶链反应和百日咳毒素(PT)IgG酶联免疫吸附试验检测百日咳杆菌:招募的儿童(n = 298)的中位数(四分位数间距,[IQR])年龄为 6.0(5.0,8.0)岁,98%的儿童接种了适当的疫苗。发现两例百日咳杆菌病例(n = 2/298,0.67%)。大多数患者(n = 246/296,83.1%)的百日咳保护性抗体(抗 PT IgG)较低:百日咳发病率较低。然而,免疫力正在显著下降。所有学龄儿童都应接种加强剂量的百日咳疫苗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Pathogens and Global Health
Pathogens and Global Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-PARASITOLOGY
CiteScore
6.00
自引率
0.00%
发文量
60
审稿时长
6-12 weeks
期刊介绍: Pathogens and Global Health is a journal of infectious disease and public health that focuses on the translation of molecular, immunological, genomics and epidemiological knowledge into control measures for global health threat. The journal publishes original innovative research papers, reviews articles and interviews policy makers and opinion leaders on health subjects of international relevance. It provides a forum for scientific, ethical and political discussion of new innovative solutions for controlling and eradicating infectious diseases, with particular emphasis on those diseases affecting the poorest regions of the world.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信