Duodenal-type follicular lymphoma: comprehensive insights into disease characteristics and established treatment strategies.

IF 2.8 4区医学 Q2 ONCOLOGY

Current Opinion in Oncology Pub Date : 2024-11-01 Epub Date: 2024-08-22 DOI:10.1097/CCO.0000000000001093

Ahmed Alnughmush, Riad El Fakih, Ruah Alyamany, Nasir Bakshi, Saud Alhayli, Mahmoud Aljurf

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引用次数: 0

Abstract

Purpose of review: This review aims to detail the characteristics and outcomes of duodenal-type follicular lymphoma (DTFL), a rare lymphoma variant. It focuses on integrating recent reports in treatment modalities and highlights emerging insights into the unique biological features of the disease.

Recent finding: Recent studies confirm the indolent nature of DTFL, with extended follow-up periods showing favorable outcomes under watchful waiting strategies and a notable proportion of patients experiencing spontaneous remission. Additionally, advancements in understanding the disease's biology revealed that the tumor microenvironment is marked by specific genomic expressions indicative of chronic inflammation.

Summary: The observations of spontaneous resolution and the generally favorable progression of DTFL call for a conservative approach in initiating treatment. Clinical management should judiciously consider the disease's typically benign course against the potential risks of intervention, promoting customized treatment protocols tailored for cases with clinical necessity. Additionally, the discovery of an inflammatory tumor microenvironment and molecular evidence suggesting an antigen-driven process highlight critical areas for future research.

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十二指肠型滤泡淋巴瘤：对疾病特征和既有治疗策略的全面了解。

综述目的：本综述旨在详细介绍十二指肠型滤泡淋巴瘤（DTFL）这一罕见淋巴瘤变种的特征和预后。综述重点整合了近期有关治疗方法的报道，并着重阐述了对该疾病独特生物学特征的新认识：最近的研究证实了 DTFL 的惰性，延长的随访期显示了观察等待策略下的良好疗效，并且有相当一部分患者经历了自发缓解。此外，随着对该疾病生物学特性认识的深入，发现肿瘤微环境中的特定基因组表达表明存在慢性炎症。总结：观察到 DTFL 的自发缓解和总体良好的进展，因此在开始治疗时应采取保守疗法。临床管理应审慎考虑该病的典型良性病程与干预的潜在风险，促进为临床必需的病例量身定制治疗方案。此外，炎症性肿瘤微环境的发现和抗原驱动过程的分子证据也凸显了未来研究的关键领域。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Oncology 医学-肿瘤学

CiteScore

6.10

自引率

2.90%

发文量

130

审稿时长

4-8 weeks

期刊介绍： With its easy-to-digest reviews on important advances in world literature, Current Opinion in Oncology offers expert evaluation on a wide range of topics from sixteen key disciplines including sarcomas, cancer biology, melanoma and endocrine tumors. Published bimonthly, each issue covers in detail the most pertinent advances in these fields from the previous year. This is supplemented by annotated references detailing the merits of the most important papers.