Targeting HSP90 in Gynecologic Cancer: Molecular Mechanisms and Therapeutic Approaches.

IF 1.8 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Biochemistry and Biophysics Pub Date : 2024-09-09 DOI:10.1007/s12013-024-01502-7

Lu Min, Xuewei Li, Lily Liang, Zheng Ruan, Shaohui Yu

引用次数: 0

Abstract

One of the leading causes of mortality for women is gynecologic cancer (GC). Numerous molecules (tumor suppressor genes or oncogenes) are involved in this form of cancer's invasion, metastasis, tumorigenic process, and therapy resistance. Currently, there is a shortage of efficient methods to eliminate these diseases, hence it is crucial to carry out more extensive studies on GCs. Novel pharmaceuticals are required to surmount this predicament. Highly conserved molecular chaperon, heat shock protein (HSP) 90, is essential for the maturation of recently produced polypeptides and offers a refuge for misfolding or denatured proteins to be turned around. In cancer, the client proteins of HSP90 play a role in the entire process of oncogenesis, which is linked to all the characteristic features of cancer. In this study, we explore the various functions of HSPs in GC progression. We also discuss their potential as promising targets for pharmacological therapy.

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针对妇科癌症中的 HSP90：分子机制与治疗方法》。

妇科癌症（GC）是导致妇女死亡的主要原因之一。许多分子（肿瘤抑制基因或致癌基因）参与了这种癌症的侵袭、转移、致瘤过程和抗药性。目前，还缺乏有效的方法来消除这些疾病，因此，对 GCs 进行更广泛的研究至关重要。要解决这一困境，就需要新的药物。高度保守的分子伴侣--热休克蛋白（HSP）90，对新产生的多肽的成熟至关重要，并为错误折叠或变性的蛋白质提供了一个转归的庇护所。在癌症中，HSP90 的客户蛋白在整个肿瘤发生过程中发挥作用，这与癌症的所有特征有关。在本研究中，我们探讨了 HSP 在 GC 进展中的各种功能。我们还讨论了它们作为药物治疗靶点的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Biochemistry and Biophysics 生物-生化与分子生物学

CiteScore

4.40

自引率

0.00%

发文量

审稿时长

7.5 months

期刊介绍： Cell Biochemistry and Biophysics (CBB) aims to publish papers on the nature of the biochemical and biophysical mechanisms underlying the structure, control and function of cellular systems The reports should be within the framework of modern biochemistry and chemistry, biophysics and cell physiology, physics and engineering, molecular and structural biology. The relationship between molecular structure and function under investigation is emphasized. Examples of subject areas that CBB publishes are: · biochemical and biophysical aspects of cell structure and function; · interactions of cells and their molecular/macromolecular constituents; · innovative developments in genetic and biomolecular engineering; · computer-based analysis of tissues, cells, cell networks, organelles, and molecular/macromolecular assemblies; · photometric, spectroscopic, microscopic, mechanical, and electrical methodologies/techniques in analytical cytology, cytometry and innovative instrument design For articles that focus on computational aspects, authors should be clear about which docking and molecular dynamics algorithms or software packages are being used as well as details on the system parameterization, simulations conditions etc. In addition, docking calculations (virtual screening, QSAR, etc.) should be validated either by experimental studies or one or more reliable theoretical cross-validation methods.