A decade update on synthesis of bicyclic β-lactams and their transformation into synthetically/biologically relevant carbocyclic and heterocyclic moieties

Abstract

Bicyclic β-lactams constitute an important class of fused-heterocyclic systems which have remained as an effective fighting tool against wide range of bacterial infections throughout 20th century. The importance of these molecules as versatile building blocks has grown exponentially in recent years. In this review, we shall discuss all the latest developments related to syntheses and reactions of bicyclic β-lactams in the last decade. This will provide useful and valuable information for understanding the behavior of bicyclic β-lactams for future development of synthetically/biologically relevant molecules.