Neuromuscular blocking agents and reversal agents

IF 0.2 Q4 ANESTHESIOLOGY

Anaesthesia and Intensive Care Medicine Pub Date : 2024-09-01 DOI:10.1016/j.mpaic.2024.07.001

Shahzaib Ahmad, Rhodri Handslip

引用次数: 0

Abstract

The neuromuscular junction is a complex structure consisting of the muscle cell, the nerve terminal of a motor neuron and the synaptic cleft. It is the site of action for neuromuscular blocking drugs, which are a cornerstone of anaesthetic practice. These drugs can be divided into depolarizing and non-depolarizing drugs; the latter can be further subdivided into benzylisoquinolinium and aminosteroid compounds. Reversal agents are also discussed. The pharmacology of neuromuscular blocking drugs and reversal agents is discussed including mechanism of action, metabolism, factors influencing choice of drug as well as adverse effect profile.

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神经肌肉阻断剂和逆转剂

神经肌肉接头是一个复杂的结构，由肌肉细胞、运动神经元的神经末梢和突触裂隙组成。它是神经肌肉阻滞药物的作用部位，是麻醉实践的基石。这些药物可分为去极化药物和非去极化药物；后者又可细分为苄基异喹啉和类氨甾化合物。此外还讨论了逆转剂。讨论了神经肌肉阻滞药物和逆转剂的药理学，包括作用机制、代谢、影响药物选择的因素以及不良反应概况。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Anaesthesia and Intensive Care Medicine ANESTHESIOLOGY-

CiteScore

0.50

自引率

0.00%

发文量

152

期刊介绍： Anaesthesia and Intensive Care Medicine, an invaluable source of up-to-date information, with the curriculum of both the Primary and Final FRCA examinations covered over a three-year cycle. Published monthly this ever-updating text book will be an invaluable source for both trainee and experienced anaesthetists. The enthusiastic editorial board, under the guidance of two eminent and experienced series editors, ensures Anaesthesia and Intensive Care Medicine covers all the key topics in a comprehensive and authoritative manner. Articles now include learning objectives and eash issue features MCQs, facilitating self-directed learning and enabling readers at all levels to test their knowledge. Each issue is divided between basic scientific and clinical sections. The basic science articles include anatomy, physiology, pharmacology, physics and clinical measurement, while the clinical sections cover anaesthetic agents and techniques, assessment and perioperative management. Further sections cover audit, trials, statistics, ethical and legal medicine, and the management of acute and chronic pain.