Exploring the influence of non-coding RNAs on NF-κB signaling pathway regulation in ulcerative colitis

IF 6.9 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Biomedicine & Pharmacotherapy Pub Date : 2024-09-08 DOI:10.1016/j.biopha.2024.117390

{"title":"Exploring the influence of non-coding RNAs on NF-κB signaling pathway regulation in ulcerative colitis","authors":"","doi":"10.1016/j.biopha.2024.117390","DOIUrl":null,"url":null,"abstract":"<div><p>The gastrointestinal tract is chronically inflamed in ulcerative colitis (UC), which has a complicated etiology involving immunological, environmental, and genetic factors. The inflammatory response that is typical of UC is significantly regulated via the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway. Latest research has displayed that NF-κB signaling is controlled by three main types of non-coding RNAs (ncRNAs): circular RNAs (circRNAs), long non-coding RNAs (lncRNAs), and microRNAs (miRNAs). These ncRNAs can change the expression of key genes within the NF-κB pathway by acting as molecular sponges, transcriptional regulators, and epigenetic modifiers. This review synthesizes current knowledge on the functions by which ncRNAs modulate NF-κB signaling in UC, discusses their potential as biomarkers for disease prognosis and diagnosis, and explores their therapeutic potential. Understanding the intricate interactions between ncRNAs and NF-κB signaling may provide novel insights into UC pathogenesis and targeted therapeutic strategies.</p></div>","PeriodicalId":8966,"journal":{"name":"Biomedicine & Pharmacotherapy","volume":null,"pages":null},"PeriodicalIF":6.9000,"publicationDate":"2024-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0753332224012757/pdfft?md5=ef7d8f03f7e65b2ca01f6886977bb60d&pid=1-s2.0-S0753332224012757-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedicine & Pharmacotherapy","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0753332224012757","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}

引用次数: 0

Abstract

The gastrointestinal tract is chronically inflamed in ulcerative colitis (UC), which has a complicated etiology involving immunological, environmental, and genetic factors. The inflammatory response that is typical of UC is significantly regulated via the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway. Latest research has displayed that NF-κB signaling is controlled by three main types of non-coding RNAs (ncRNAs): circular RNAs (circRNAs), long non-coding RNAs (lncRNAs), and microRNAs (miRNAs). These ncRNAs can change the expression of key genes within the NF-κB pathway by acting as molecular sponges, transcriptional regulators, and epigenetic modifiers. This review synthesizes current knowledge on the functions by which ncRNAs modulate NF-κB signaling in UC, discusses their potential as biomarkers for disease prognosis and diagnosis, and explores their therapeutic potential. Understanding the intricate interactions between ncRNAs and NF-κB signaling may provide novel insights into UC pathogenesis and targeted therapeutic strategies.

查看原文本刊更多论文

探索非编码 RNA 对溃疡性结肠炎 NF-κB 信号通路调控的影响

溃疡性结肠炎（UC）的病因复杂，涉及免疫、环境和遗传因素，胃肠道长期处于炎症状态。溃疡性结肠炎的典型炎症反应在很大程度上受活化 B 细胞的核因子卡巴轻链增强子（NF-κB）信号通路的调控。最新研究表明，NF-κB 信号通路主要由三种非编码 RNA（ncRNA）控制：环状 RNA（circRNA）、长非编码 RNA（lncRNA）和 microRNA（miRNA）。这些非编码 RNA 可作为分子海绵、转录调节因子和表观遗传修饰因子，改变 NF-κB 通路中关键基因的表达。这篇综述综述了目前有关 ncRNA 在 UC 中调节 NF-κB 信号转导的功能的知识，讨论了它们作为疾病预后和诊断生物标志物的潜力，并探讨了它们的治疗潜力。了解 ncRNA 与 NF-κB 信号传导之间错综复杂的相互作用可能会为了解 UC 发病机制和靶向治疗策略提供新的视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Biomedicine & Pharmacotherapy 医学-药学

CiteScore

11.90

自引率

2.70%

发文量

1621

审稿时长

48 days

期刊介绍： Biomedicine & Pharmacotherapy stands as a multidisciplinary journal, presenting a spectrum of original research reports, reviews, and communications in the realms of clinical and basic medicine, as well as pharmacology. The journal spans various fields, including Cancer, Nutriceutics, Neurodegenerative, Cardiac, and Infectious Diseases.