Neuronal AMPK regulates lipid transport to microglia.

IF 13 1区生物学 Q1 CELL BIOLOGY

Trends in Cell Biology Pub Date : 2024-09-01 DOI:10.1016/j.tcb.2024.08.001

Ju-Young Bae, Julie Jacquemyn, Maria S Ioannou

引用次数: 0

Abstract

In neurodegeneration, neurons release lipids that accumulate in glial lipid droplets (LDs). But what controls lipid transport and how does this affect glia? A recent study by Li et al. discovered that the loss of neuronal AMP-activated protein kinase (AMPK) activity promotes lipid efflux, which drives a proinflammatory state in microglia.

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神经元 AMPK 调节向小胶质细胞的脂质运输

在神经变性过程中，神经元会释放脂质，这些脂质会积聚在胶质细胞脂滴（LD）中。但是，是什么控制了脂质的运输，这又是如何影响胶质细胞的呢？李等人最近的一项研究发现，神经元 AMP 激活蛋白激酶（AMPK）活性的丧失会促进脂质外流，从而推动小胶质细胞的促炎状态。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Cell Biology 生物-细胞生物学

CiteScore

32.00

自引率

0.50%

发文量

160

审稿时长

61 days

期刊介绍： Trends in Cell Biology stands as a prominent review journal in molecular and cell biology. Monthly review articles track the current breadth and depth of research in cell biology, reporting on emerging developments and integrating various methods, disciplines, and principles. Beyond Reviews, the journal features Opinion articles that follow trends, offer innovative ideas, and provide insights into the implications of new developments, suggesting future directions. All articles are commissioned from leading scientists and undergo rigorous peer-review to ensure balance and accuracy.