Retrospective study of hepatitis C screening and seroprevalence in the GHU Paris.

IF 1.2 4区 医学 Q4 NEUROSCIENCES
Alexandra Pham-Scottez, Valérie Dauriac-Le Masson, Oumeyma Ben Dahman, Armel Toquin, Amine Benmostefa, Nabil Hallouche
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Abstract

Objectives: The prevalence of hepatitis C virus (HCV) has been estimated to be approximately ten times higher in patients with psychiatric disorders, but European data are rare and only two French studies have recently been published on the subject. Our objective was to determine the HCV screening rate and the prevalence of HCV in adult patients hospitalised in the largest French psychiatric hospital.

Methods: We conducted a retrospective study of all adult patients hospitalised at GHU Paris, from 2019 to 2022, including age, gender, HCV screening, HCV serological status, and the existence of an ICD-10 diagnosis of psychoactive substance use disorder. Descriptive statistics used means±standard deviations and percentages. Bivariable comparisons used Student's t test and Chi-square test.

Results: The overall HCV screening rate was 55.4% and increased over the four years from 37.1% in 2019 to 69.4% in 2022. Patients screened were significantly younger people and with a substance use disorder than unscreened patients. The prevalence of HCV over this 4-year period was 2.8% and remained stable. The HCV-positive patients were significantly more male, older and more likely to have substance use disorders than the HCV-negative patients.

Conclusions: We found a prevalence rate of HCV ten times higher than the prevalence in the general population, in line with findings in many other European countries. The eradication of HCV will not be possible without the elimination of this "forgotten reservoir" of the virus. Efforts must be made in psychiatric hospitals to test all patients in order to treat patients suffering from hepatitis C with direct-acting antivirals.

巴黎 GHU 的丙型肝炎筛查和血清阳性率回顾性研究。
研究目的据估计,丙型肝炎病毒(HCV)在精神障碍患者中的流行率大约是普通患者的十倍,但欧洲的相关数据非常罕见,最近也仅有两项法国研究公布了相关数据。我们的目标是确定法国最大的精神病医院中住院的成年患者的丙型肝炎病毒筛查率和丙型肝炎病毒感染率:我们对 2019 年至 2022 年在巴黎 GHU 住院的所有成年患者进行了一项回顾性研究,包括年龄、性别、HCV 筛查、HCV 血清学状态以及是否存在 ICD-10 精神活性物质使用障碍诊断。描述性统计采用均值±标准差和百分比。双变量比较采用学生 t 检验和卡方检验:总体HCV筛查率为55.4%,四年内从2019年的37.1%增至2022年的69.4%。与未接受筛查的患者相比,接受筛查的患者明显更年轻,且有药物使用障碍。在这 4 年中,HCV 感染率为 2.8%,并保持稳定。与 HCV 阴性患者相比,HCV 阳性患者中男性明显更多,年龄更大,更有可能患有药物使用障碍:我们发现,HCV 感染率是普通人群感染率的十倍,这与许多其他欧洲国家的研究结果一致。如果不消除这一 "被遗忘的病毒库",就不可能根除丙型肝炎病毒。精神病院必须努力对所有患者进行检测,以便用直接作用抗病毒药物治疗丙型肝炎患者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.60
自引率
7.40%
发文量
162
审稿时长
6-12 weeks
期刊介绍: Une revue française de renommée internationale. - Un comite de rédaction représentant tous les aspects de la prise en charge psychiatrique du patient. - Une sélection rigoureuse d''articles faisant l''objet de plusieurs expertises. - Des travaux d''auteurs et de chercheurs de renommée internationale. - Des indexations dans les grandes bases de données (Current Contents, Excerpta Medica, etc.). - Un facteur d''impact qui témoigne de la grande notoriété de la revue. La tribune des publications originales de haut niveau. - Une très grande diversité des sujets traités, rigoureusement sélectionnés à travers des sommaires dynamiques : - des éditoriaux de médecins référents, - une revue de presse sur les actualités internationales, - des articles originaux pour approfondir vos connaissances, - des mises au point et des cas cliniques pour engager votre réflexion sur les indications et choix possibles au travers de mises en situation clinique, - des dossiers thématiques pour faire le tour d''une question. - L''actualité de l''AFPB : L''Encéphale publie régulièrement des comptes rendus de l''Association française de psychiatrie clinique.
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