Frailty in Persons with Down Syndrome: Results from the REVIVIS Study

IF 4.2 2区医学 Q2 GERIATRICS & GERONTOLOGY

Journal of the American Medical Directors Association Pub Date : 2024-09-04 DOI:10.1016/j.jamda.2024.105239

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引用次数: 0

Abstract

Objectives

To determine frailty prevalence and identify possible nonclinical factors associated with this condition in community-dwelling individuals with Down syndrome (DS).

Design

Cross-sectional analysis of the registry study REVIVIS, a single-center, prospective study on the geriatric management of persons with DS.

Setting and Participants

Individuals with DS (n = 139) referred to a geriatric clinic.

Methods

Frailty was assessed through a 38-item Frailty Index (FI). A multivariable linear regression model was performed to assess the relationship between frailty and different variables of interest: age, number of prescribed drugs, and employment status (unemployed vs employed).

Results

Among 139 subjects (54.5% male), mean (SD) aged 42.9 (6.9) years, the median (interquartile range) FI was 0.24 (0.16-0.30) with 60 participants (43.2%) classified as frail. The number of prescribed medications was associated with higher FI levels (P < .001), whereas being employed was associated with lower FI levels (P < .001) compared with being unemployed. No association was found between chronological age and FI.

Conclusions and Implications

Our findings suggest that chronological age is insufficient to encompass the complexity of a subject with DS, underscoring the importance of a standardized evaluation of the FI among this population. Access to geriatric care might become an important opportunity for people with DS, a population characterized by high vulnerability (or frailty).

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唐氏综合症患者的虚弱：REVIVIS 研究结果

目的确定唐氏综合征（DS）患者在社区生活中的体弱患病率，并找出可能与此相关的非临床因素：对 REVIVIS 登记研究进行横断面分析，这是一项关于唐氏综合征患者老年病管理的单中心前瞻性研究：方法：通过 38 分法评估虚弱程度：方法：通过包含 38 个项目的虚弱指数 (FI) 进行评估。结果：139 名受试者中（54.5%），年龄、处方药数量和就业状况（失业与在职）等不同变量之间的关系通过多变量线性回归模型进行了评估：在 139 名平均（标清）年龄为 42.9（6.9）岁的受试者（54.5% 为男性）中，FI 的中位数（四分位数间距）为 0.24（0.16-0.30），60 名受试者（43.2%）被归类为体弱者。处方药的数量与较高的 FI 水平相关（P < .001），而与失业者相比，在职者的 FI 水平较低（P < .001）。未发现计时年龄与 FI 之间有任何关联：我们的研究结果表明，按时间计算的年龄不足以涵盖 DS 患者的复杂性，这凸显了对这一人群的 FI 进行标准化评估的重要性。对于具有高脆弱性（或虚弱）特征的 DS 患者来说，获得老年护理可能是一个重要的机会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the American Medical Directors Association 医学-老年医学

CiteScore

11.10

自引率

6.60%

发文量

472

审稿时长

44 days

期刊介绍： JAMDA, the official journal of AMDA - The Society for Post-Acute and Long-Term Care Medicine, is a leading peer-reviewed publication that offers practical information and research geared towards healthcare professionals in the post-acute and long-term care fields. It is also a valuable resource for policy-makers, organizational leaders, educators, and advocates. The journal provides essential information for various healthcare professionals such as medical directors, attending physicians, nurses, consultant pharmacists, geriatric psychiatrists, nurse practitioners, physician assistants, physical and occupational therapists, social workers, and others involved in providing, overseeing, and promoting quality