The Tiny Big Difference: Nanotechnology in Photoprotective Innovations – A Systematic Review

IF 3.4 4区医学 Q2 PHARMACOLOGY & PHARMACY

AAPS PharmSciTech Pub Date : 2024-09-07 DOI:10.1208/s12249-024-02925-4

José Adão Carvalho Nascimento Júnior, Anamaria Mendonça Santos, Ana Maria Santos Oliveira, Alcimary Bispo Santos, Adriano Antunes de Souza Araújo, Diana Marcela Aragón, Luiza Abrahão Frank, Mairim Russo Serafini

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Abstract

UV radiation causes long- and short-term skin damage, such as erythema and skin cancer. Therefore, the use of sunscreens is extremely important. However, concerns about UV filter safety have prompted exploration into alternative solutions, with nanotechnology emerging as a promising avenue. This systematic review identified 23 experimental studies utilizing nanocarriers to encapsulate sunscreens with the aim of enhancing their efficacy and safety. Polymeric and lipid nanoparticles are frequently employed to encapsulate both organic and inorganic UV filters along with natural antioxidants. Nanocarriers have demonstrated benefits including reduced active ingredient usage, increased sun protection factor, and mitigated photoinstability. Notably, they also decreased the skin absorption of UV filters. In summary, nanocarriers represent a viable strategy for improving sunscreen formulations, offering enhanced physicochemical properties and bolstered photoprotective effects, thereby addressing concerns regarding UV filter safety and efficacy in cosmetic applications.

Graphical Abstract

Abstract Image

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微小的巨大差异：光保护创新中的纳米技术--系统综述。

紫外线辐射会造成长期和短期的皮肤损伤，如红斑和皮肤癌。因此，使用防晒霜极为重要。然而，人们对紫外线过滤器安全性的担忧促使人们探索替代解决方案，而纳米技术则是一种前景广阔的途径。本系统综述确定了 23 项利用纳米载体封装防晒霜的实验研究，旨在提高防晒霜的功效和安全性。聚合物和脂质纳米颗粒经常被用来封装有机和无机紫外线过滤剂以及天然抗氧化剂。纳米载体的优点包括减少活性成分用量、提高防晒系数和降低光稳定性。值得注意的是，它们还能减少皮肤对紫外线过滤剂的吸收。总之，纳米载体是改进防晒配方的一种可行策略，它具有更强的物理化学特性和更强的光保护效果，从而解决了人们对化妆品中紫外线过滤剂安全性和有效性的担忧。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

AAPS PharmSciTech 医学-药学

CiteScore

6.80

自引率

3.00%

发文量

264

审稿时长

2.4 months

期刊介绍： AAPS PharmSciTech is a peer-reviewed, online-only journal committed to serving those pharmaceutical scientists and engineers interested in the research, development, and evaluation of pharmaceutical dosage forms and delivery systems, including drugs derived from biotechnology and the manufacturing science pertaining to the commercialization of such dosage forms. Because of its electronic nature, AAPS PharmSciTech aspires to utilize evolving electronic technology to enable faster and diverse mechanisms of information delivery to its readership. Submission of uninvited expert reviews and research articles are welcomed.