Symptom clusters and impact on quality of life in lung cancer patients undergoing chemotherapy.

IF 3.3 3区医学 Q1 HEALTH CARE SCIENCES & SERVICES

Quality of Life Research Pub Date : 2024-12-01 Epub Date: 2024-09-06 DOI:10.1007/s11136-024-03778-x

Yuanyuan Luo, Le Zhang, Dongmei Mao, Zhihui Yang, Benxiang Zhu, Jingxia Miao, Lili Zhang

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Abstract

Purpose: To identify symptom clusters (SCs) in lung cancer patients undergoing chemotherapy and explore their impact on health-related quality of life (HRQoL).

Methods: Patients were invited to complete the Chinese version of the M.D. Anderson Symptom Inventory with the Lung Cancer Module and the Quality of Life Questionnaire-core 30. Network analysis was employed to identify SCs. The associations between SCs and each function of HRQoL were examined using the Pearson correlation matrix. Multiple linear regression was applied to analyze the influencing factors of each function of HRQoL.

Results: A total of 623 lung cancer patients who were receiving chemotherapy were recruited. The global health status of lung cancer patients was 59.71 ± 21.09, and 89.73% of patients developed symptoms. Three SCs (Somato-psychological SC, Respiratory SC, and Gastrointestinal SC) were identified, and Somato-psychological SC and Gastrointestinal SC were identified as influencing factors for HRQoL in lung cancer patients.

Conclusion: Most lung cancer patients who undergo chemotherapy experience a range of symptoms, which can be categorized into three SCs. The Somato-psychological SC and Gastrointestinal SC negatively impacted patients' HRQoL. Health care providers should prioritize monitoring these SCs to identify high-risk patients early and implement targeted preventive and intervention measures for each SC, aiming to alleviate symptom burden and enhance HRQoL.

Abstract Image

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接受化疗的肺癌患者的症状群及其对生活质量的影响。

目的：确定接受化疗的肺癌患者的症状群（SCs），并探讨其对健康相关生活质量（HRQoL）的影响：方法：邀请患者填写中文版M.D. Anderson症状量表肺癌模块和生活质量问卷-核心30。采用网络分析来识别SCs。利用皮尔逊相关矩阵检验了SC与HRQoL各功能之间的关联。采用多元线性回归分析 HRQoL 各项功能的影响因素：共招募了 623 名接受化疗的肺癌患者。肺癌患者的总体健康状况为（59.71±21.09）分，89.73%的患者出现症状。研究发现了三个SC（躯体心理SC、呼吸系统SC和胃肠道SC），其中躯体心理SC和胃肠道SC是肺癌患者HRQoL的影响因素：结论：大多数接受化疗的肺癌患者会出现一系列症状，这些症状可分为三种SC。躯体-心理 SC 和胃肠道 SC 对患者的 HRQoL 有负面影响。医护人员应优先监测这些SC，及早发现高危患者，并针对每种SC实施有针对性的预防和干预措施，以减轻症状负担，提高患者的HRQoL。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Quality of Life Research 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.50

自引率

8.60%

发文量

224

审稿时长

3-8 weeks

期刊介绍： Quality of Life Research is an international, multidisciplinary journal devoted to the rapid communication of original research, theoretical articles and methodological reports related to the field of quality of life, in all the health sciences. The journal also offers editorials, literature, book and software reviews, correspondence and abstracts of conferences. Quality of life has become a prominent issue in biometry, philosophy, social science, clinical medicine, health services and outcomes research. The journal''s scope reflects the wide application of quality of life assessment and research in the biological and social sciences. All original work is subject to peer review for originality, scientific quality and relevance to a broad readership. This is an official journal of the International Society of Quality of Life Research.