Inadvertent Orbital Mitomycin C Injection as a Cause of Ptosis and Ophthalmoplegia from Orbital Necrosis.

IF 1.2 4区 医学 Q3 OPHTHALMOLOGY
Ryan H Mason, Kenneth Chang, Georges Nassrallah, David B Yan, Dan D DeAngelis
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引用次数: 0

Abstract

Mitomycin C is an alkylating agent with the ability to suppress fibroblast proliferation and activity, making it a powerful antifibrotic. It has therefore become popular in glaucoma filtering surgeries, used both intraoperatively during bleb formation and postoperatively as an adjunct to bleb needling. This report presents a rare but serious risk of bleb needling with Mitomycin C at the slit lamp, where inadvertent movement of the patient resulted in an orbital injection. The patient quickly developed focal tissue inflammation and necrosis, presenting one day after the procedure with complete ptosis, ophthalmoplegia, and a palpable orbital mass. After appropriate imaging and an excisional biopsy to exclude infectious, infiltrative, and neoplastic causes, this was managed with close observation and continued improvement, and resolution of most orbital sequelae.

无意中眼眶注射丝裂霉素 C 导致眼眶坏死引起上睑下垂和眼肌麻痹。
丝裂霉素 C 是一种烷化剂,能够抑制成纤维细胞的增殖和活性,是一种强效抗纤维化药物。因此,它在青光眼滤过手术中很受欢迎,在术中形成眼泡和术后作为眼泡针刺的辅助药物使用。本报告介绍了在裂隙灯下使用丝裂霉素 C 进行眼泡针刺的罕见但严重的风险。患者很快出现局灶性组织炎症和坏死,术后一天出现完全性上睑下垂、眼肌麻痹和可触及的眼眶肿块。经过适当的影像学检查和切除活检,排除了感染、浸润和肿瘤等病因,经过密切观察和持续改善,大部分眼眶后遗症得到了缓解。
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来源期刊
CiteScore
2.50
自引率
10.00%
发文量
322
审稿时长
3-8 weeks
期刊介绍: Ophthalmic Plastic and Reconstructive Surgery features original articles and reviews on topics such as ptosis, eyelid reconstruction, orbital diagnosis and surgery, lacrimal problems, and eyelid malposition. Update reports on diagnostic techniques, surgical equipment and instrumentation, and medical therapies are included, as well as detailed analyses of recent research findings and their clinical applications.
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