Lei Fang, Yunxia Song, Haifeng Jin, Yinyin Liu, Shaohua Gou
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引用次数: 0
Abstract
To search for novel anti-Alzheimer agents, multifunctional Fe3O4-based nanoparticles (FSSIO) is designed and prepared which contain ferulic acid (FA) and Simvastatin linked to the surface of Fe3O4 particles. In vitro tests confirmed that FSSIO possessed favorable biocompatibility and a pronounced ability to penetrate blood brain barrier. The FA moiety endowed the particles with remarkable antioxidant and anti-inflammatory properties, and effectively protected neuron cells from the toxicity induced by Aβ. Moreover, the Simvastatin pharmacophore assists the particles up-regulate the expression level of BDNF and significantly promotes the expression levels of p-TrkB, p-ERK, p-PI3K and Akt, which consequently leads to the neurite outgrowth via regulating PI3K/ATK and TrkB-mediated signaling pathway. More importantly, in the Morris water maze test, FSSIO shows excellent activity to enhance the learning and memory retention of AD model rats.
为寻找新型抗老年痴呆药物，设计并制备了基于Fe3O4的多功能纳米颗粒（FSSIO），该颗粒含有阿魏酸（FA）和辛伐他汀，并与Fe3O4颗粒表面相连。体外试验证实，FSSIO 具有良好的生物相容性和穿透血脑屏障的能力。FA分子使颗粒具有显著的抗氧化和抗炎特性，并能有效保护神经元细胞免受Aβ的毒性。此外，辛伐他汀的药理作用还能帮助颗粒上调BDNF的表达水平，并显著促进p-TrkB、p-ERK、p-PI3K和Akt的表达水平，从而通过调节PI3K/ATK和TrkB介导的信号通路促进神经元的生长。更重要的是，在莫里斯水迷宫试验中，FSSIO 在提高 AD 模型大鼠的学习和记忆保持能力方面表现出卓越的活性。
期刊介绍：
Small serves as an exceptional platform for both experimental and theoretical studies in fundamental and applied interdisciplinary research at the nano- and microscale. The journal offers a compelling mix of peer-reviewed Research Articles, Reviews, Perspectives, and Comments.
With a remarkable 2022 Journal Impact Factor of 13.3 (Journal Citation Reports from Clarivate Analytics, 2023), Small remains among the top multidisciplinary journals, covering a wide range of topics at the interface of materials science, chemistry, physics, engineering, medicine, and biology.
Small's readership includes biochemists, biologists, biomedical scientists, chemists, engineers, information technologists, materials scientists, physicists, and theoreticians alike.
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