Gold-Catalyzed Alkyne Oxidative Cyclization/Mannich-Type Addition Cascade Reaction of Ynamides with 1,3,5-Triazinanes.

IF 3.3 2区化学 Q1 CHEMISTRY, ORGANIC

The Journal of Organic Chemistry Pub Date : 2024-09-20 Epub Date: 2024-09-05 DOI:10.1021/acs.joc.4c01784

Kewei Chen, Chao Li, Shanliang Dong, Kemiao Hong, Jingjing Huang, Xinfang Xu

引用次数: 0

Abstract

Herein, a gold-catalyzed alkyne oxidative cyclization/Mannich-type addition cascade reaction of ynamides with 1,3,5-triazinanes in the presence of a Brønsted acid has been presented. A class of functionalized fluorenes bearing a quaternary carbon center was synthesized directly with moderate to excellent yields via in situ formed α-oxo carbenes using quinoline N-oxide as the oxidant under mild reaction conditions.

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金催化的炔烃氧化环化/1,3,5-三嗪酰胺的曼尼希式加成级联反应。

本文介绍了一种金催化的炔氧化环化/曼尼希式加成级联反应，在布氏酸存在下，炔酰胺与 1,3,5-三嗪酮发生反应。在温和的反应条件下，使用喹啉 N-氧化物作为氧化剂，通过原位形成的 α-氧代碳烯直接合成了一类带有季碳中心的官能化芴，收率中等到极好。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

The Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： The Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.