An alternative and scalable synthesis for Relugolix

IF 2.1 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2024-09-02 DOI:10.1016/j.tet.2024.134243

引用次数: 0

Abstract

An alternative and efficient synthetic route for Relugolix was accomplished by changing the construction order of three main parts A, B and C. After the optimization, its scale-up of the preparation for Relogulix was completed in a seven-step methodology with overall yield of 61 % and 99.62 % HPLC purity.

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一种可替代和可扩展的瑞乐高合成方法

通过改变 A、B 和 C 三个主要部分的结构顺序，完成了 Relugolix 的替代性高效合成路线。经过优化后，通过七步方法完成了 Relogulix 的放大制备，总收率为 61%，HPLC 纯度为 99.62%。

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.