Tranexamic Acid in Mohs Micrographic Surgery: A Systematic Review.

IF 2.5 3区医学 Q2 DERMATOLOGY

Dermatologic Surgery Pub Date : 2024-09-05 DOI:10.1097/DSS.0000000000004373

Eenika A Kumar, Lisa M Morris, Basia M Michalski-McNeely

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引用次数: 0

Abstract

Background: Tranexamic acid (TXA) is an antifibrinolytic that has historically been used to treat menorrhagia and bleeding disorders. Exploration of its use in procedures has grown, and it has shown promise in its ability to achieve hemostasis with low risk to patients. Analysis of its use in Mohs micrographic surgery (MMS) is warranted due to its potential superiority to traditional methods of achieving hemostasis (direct pressure, electrocoagulation, and sutures).

Objective: To perform a systematic review of studies which evaluate the efficacy and safety profile of topical application or subcutaneous injection of TXA and analyze as it applies to MMS.

Materials and methods: A comprehensive literature search was conducted using the PubMed database to identify relevant studies using the search terms: "tranexamic acid" OR "TXA." The search was performed up to December 1, 2023.

Results: Tranexamic acid has a strong safety profile, and its effectiveness in achieving hemostasis is well-demonstrated. Tranexamic acid has reduced risk of bleeding complications compared with traditional methods of achieving hemostasis.

Conclusion: An extensive review of the literature has yielded positive results, suggesting the potential of TXA in improving patient outcomes, reducing surgical time, decreasing intraoperative and postoperative bleeding, and increasing overall patient satisfaction.

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氨甲环酸在莫氏显微摄影手术中的应用：系统综述。

背景：氨甲环酸（TXA）是一种抗纤维蛋白溶解剂，历来用于治疗月经过多和出血性疾病。在外科手术中使用氨甲环酸的情况越来越多，而且它在低风险止血方面表现出了良好的前景。由于其止血效果可能优于传统止血方法（直接加压、电凝和缝合），因此有必要对其在莫氏显微摄影手术（MMS）中的应用进行分析：对评估局部应用或皮下注射 TXA 的有效性和安全性的研究进行系统综述，并分析其在 MMS 中的应用：使用 PubMed 数据库进行了全面的文献检索，以确定相关研究，检索词为："氨甲环酸 "或 "TXA"："氨甲环酸 "或 "TXA"。检索时间截至 2023 年 12 月 1 日：氨甲环酸具有很高的安全性，其止血效果也得到了充分证明。与传统止血方法相比，氨甲环酸可降低出血并发症的风险：广泛的文献综述得出了积极的结果，表明氨甲环酸在改善患者预后、缩短手术时间、减少术中和术后出血以及提高患者总体满意度方面具有潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dermatologic Surgery 医学-皮肤病学

CiteScore

3.10

自引率

16.70%

发文量

547

期刊介绍： Exclusively devoted to dermatologic surgery, the Dermatologic Surgery journal publishes the most clinically comprehensive and up-to-date information in its field. This unique monthly journal provides today’s most expansive and in-depth coverage of cosmetic and reconstructive skin surgery and skin cancer through peer-reviewed original articles, extensive illustrations, case reports, ongoing features, literature reviews and correspondence. The journal provides information on the latest scientific information for all types of dermatologic surgery including: -Ambulatory phlebectomy- Blepharoplasty- Body contouring- Chemical peels- Cryosurgery- Curettage and desiccation- Dermabrasion- Excision and closure- Flap Surgery- Grafting- Hair restoration surgery- Injectable neuromodulators- Laser surgery- Liposuction- Microdermabrasion- Microlipoinjection- Micropigmentation- Mohs micrographic surgery- Nail surgery- Phlebology- Sclerotherapy- Skin cancer surgery- Skin resurfacing- Soft-tissue fillers. Dermatologists, dermatologic surgeons, plastic surgeons, oculoplastic surgeons and facial plastic surgeons consider this a must-read publication for anyone in the field.