Improved conditions for the synthesis of tertiary fluorides using a KF/H2SO4 combination

IF 1.7 4区化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Journal of Fluorine Chemistry Pub Date : 2024-08-30 DOI:10.1016/j.jfluchem.2024.110338

Xavier Bertrand , Doria Aissaoui , Océane Meryem Col , Mathieu Pucheault , Laurent Chabaud , Jean-François Paquin

引用次数: 0

Abstract

In this paper, we report the deoxyfluorination of tertiary alcohol using a simple combination of potassium fluoride and sulfuric acid. These cheap and widely available reagents allow for the synthesis of tertiary fluorides in good to excellent yields. Extension of the reaction to other functional groups such as alkenes, acetates and ethers have also been studied.

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利用 KF/H2SO4 组合合成三氟化物的改进条件

在本文中，我们报告了使用氟化钾和硫酸的简单组合对叔醇进行脱氧氟化的过程。这些廉价且广泛使用的试剂能够以良好甚至极佳的收率合成叔氟化物。此外，还研究了将该反应扩展到烯、醋酸盐和醚等其他官能团的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Fluorine Chemistry 化学-无机化学与核化学

CiteScore

3.80

自引率

10.50%

发文量

审稿时长

33 days

期刊介绍： The Journal of Fluorine Chemistry contains reviews, original papers and short communications. The journal covers all aspects of pure and applied research on the chemistry as well as on the applications of fluorine, and of compounds or materials where fluorine exercises significant effects. This can include all chemistry research areas (inorganic, organic, organometallic, macromolecular and physical chemistry) but also includes papers on biological/biochemical related aspects of Fluorine chemistry as well as medicinal, agrochemical and pharmacological research. The Journal of Fluorine Chemistry also publishes environmental and industrial papers dealing with aspects of Fluorine chemistry on energy and material sciences. Preparative and physico-chemical investigations as well as theoretical, structural and mechanistic aspects are covered. The Journal, however, does not accept work of purely routine nature. For reviews and special issues on particular topics of fluorine chemistry or from selected symposia, please contact the Regional Editors for further details.