High Rates of Nonsusceptibility to Common Oral Antibiotics in Streptococcus pneumoniae Clinical Isolates From the United States (2019-2021).

IF 3.8 4区医学 Q2 IMMUNOLOGY

Open Forum Infectious Diseases Pub Date : 2024-08-22 eCollection Date: 2024-09-01 DOI:10.1093/ofid/ofae470

Lalitagauri M Deshpande, Michael D Huband, Sarah Charbon, Mariana Castanheira, Rodrigo E Mendes

引用次数: 0

Abstract

Streptococcus pneumoniae isolates from the United States (n = 1038; 2019-2021) were susceptible to omadacycline (99.8%), levofloxacin (99.7%), and ceftriaxone (98.1%), whereas doxycycline (80.2%), oral penicillin (63.5%), cefpodoxime (76.8%), and azithromycin (54.4%) activity was limited. Tet(M) did not affect omadacycline activity but altered activity of older tetracyclines including doxycycline, suggesting omadacycline is an important option for treatment of community-acquired bacterial pneumonia.

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美国肺炎链球菌临床分离株对常用口服抗生素的高不敏感率（2019-2021 年）。

来自美国的肺炎链球菌分离株（n = 1038；2019-2021年）对奥美拉唑（99.8%）、左氧氟沙星（99.7%）和头孢曲松（98.1%）敏感，而对强力霉素（80.2%）、口服青霉素（63.5%）、头孢泊肟（76.8%）和阿奇霉素（54.4%）的活性有限。Tet(M)不影响奥马大环素的活性，但会改变包括多西环素在内的老式四环素的活性，这表明奥马大环素是治疗社区获得性细菌性肺炎的一个重要选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Forum Infectious Diseases Medicine-Neurology (clinical)

CiteScore

6.70

自引率

4.80%

发文量

630

审稿时长

9 weeks

期刊介绍： Open Forum Infectious Diseases provides a global forum for the publication of clinical, translational, and basic research findings in a fully open access, online journal environment. The journal reflects the broad diversity of the field of infectious diseases, and focuses on the intersection of biomedical science and clinical practice, with a particular emphasis on knowledge that holds the potential to improve patient care in populations around the world. Fully peer-reviewed, OFID supports the international community of infectious diseases experts by providing a venue for articles that further the understanding of all aspects of infectious diseases.