Daren Esteban Araque Gualtero, Diego Augusto Moreno Diaz, Julie Melissa Mogollón, Andrés Felipe Gómez Rueda
{"title":"Acquired thrombotic thrombocytopenic purpura in a patient with plasmodium vivax malaria: A case report.","authors":"Daren Esteban Araque Gualtero, Diego Augusto Moreno Diaz, Julie Melissa Mogollón, Andrés Felipe Gómez Rueda","doi":"10.1590/0037-8682-0014-2024","DOIUrl":null,"url":null,"abstract":"<p><p>Acquired thrombotic thrombocytopenic purpura (TTP) is a rare life-threatening disorder characterized by microangiopathic hemolytic anemia, severe thrombocytopenia, and organ damage. We present the case of a 71-year-old man initially diagnosed with malaria-like symptoms and displaying markers of microangiopathic hemolytic anemia, severe thrombocytopenia, renal injury, and neurological impairment. Despite antimalarial treatment, acquired TTP was suspected. Plasma exchange and immunosuppressive therapy led to clinical improvement, normalizing the platelet count and hemolytic profile. Diagnostic confirmation revealed significantly reduced ADAMTS13 levels. Following the proposed treatment, the patient's ADAMTS13 levels normalized. This case illustrates acquired TTP linked to uncomplicated Plasmodium vivax malaria.</p>","PeriodicalId":21199,"journal":{"name":"Revista da Sociedade Brasileira de Medicina Tropical","volume":null,"pages":null},"PeriodicalIF":1.8000,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11374122/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista da Sociedade Brasileira de Medicina Tropical","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1590/0037-8682-0014-2024","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"PARASITOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Acquired thrombotic thrombocytopenic purpura (TTP) is a rare life-threatening disorder characterized by microangiopathic hemolytic anemia, severe thrombocytopenia, and organ damage. We present the case of a 71-year-old man initially diagnosed with malaria-like symptoms and displaying markers of microangiopathic hemolytic anemia, severe thrombocytopenia, renal injury, and neurological impairment. Despite antimalarial treatment, acquired TTP was suspected. Plasma exchange and immunosuppressive therapy led to clinical improvement, normalizing the platelet count and hemolytic profile. Diagnostic confirmation revealed significantly reduced ADAMTS13 levels. Following the proposed treatment, the patient's ADAMTS13 levels normalized. This case illustrates acquired TTP linked to uncomplicated Plasmodium vivax malaria.
期刊介绍：
The Journal of the Brazilian Society of Tropical Medicine (JBSTM) isan official journal of the Brazilian Society of Tropical Medicine) with open access. It is amultidisciplinary journal that publishes original researches related totropical diseases, preventive medicine, public health, infectious diseasesand related matters. Preference for publication will be given to articlesreporting original observations or researches. The journal has a peer-reviewsystem for articles acceptance and its periodicity is bimonthly. The Journalof the Brazilian Society of Tropical Medicine is published in English.The journal invites to publication Major Articles, Editorials, Reviewand Mini-Review Articles, Short Communications, Case Reports, TechnicalReports, Images in Infectious Diseases, Letters, Supplements and Obituaries.
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