Prognostic risk factors for pyogenic liver abscess caused by Klebsiella pneumoniae.

IF 2.5 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

BMC Gastroenterology Pub Date : 2024-09-03 DOI:10.1186/s12876-024-03391-9

Yunxiao Lyu, Bin Wang

{"title":"Prognostic risk factors for pyogenic liver abscess caused by Klebsiella pneumoniae.","authors":"Yunxiao Lyu, Bin Wang","doi":"10.1186/s12876-024-03391-9","DOIUrl":null,"url":null,"abstract":"Background: Pyogenic liver abscess (PLA) caused by Klebsiella pneumoniae can vary in severity, and several risk factors for the development of organ dysfunction in PLA have been implicated. However, few studies to date have explored the most common risk factors for clinical severity.Methods: We conducted a study on patients with PLA caused by Klebsiella pneumoniae between February 2013 and December 2022.Using logistic regression analysis, we sought to identify factors associated with positive blood culture, septic shock, and intensive care unit (ICU) admission.Results: After included 200 patients, we found that an elevated procalcitonin (PCT) level (p = 0.03), higher glucose level (p = 0.03), and lower total cholesterol (TC) level (p = 0.01) were associated with a higher likelihood of positive blood bacteriological culture. Additionally, an increased PCT level (p = 0.02) and lower TC level (p < 0.01) were associated with an elevated risk of septic shock. Furthermore, a higher PCT level (p < 0.01) was associated with a higher probability of ICU admission.Conclusion: In patients with PLA caused by Klebsiella pneumoniae, the PCT, glucose, and TC levels were found to be associated with positive blood culture, septic shock, and ICU admission.","PeriodicalId":9129,"journal":{"name":"BMC Gastroenterology","volume":null,"pages":null},"PeriodicalIF":2.5000,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11373132/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Gastroenterology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12876-024-03391-9","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Pyogenic liver abscess (PLA) caused by Klebsiella pneumoniae can vary in severity, and several risk factors for the development of organ dysfunction in PLA have been implicated. However, few studies to date have explored the most common risk factors for clinical severity.

Methods: We conducted a study on patients with PLA caused by Klebsiella pneumoniae between February 2013 and December 2022.Using logistic regression analysis, we sought to identify factors associated with positive blood culture, septic shock, and intensive care unit (ICU) admission.

Results: After included 200 patients, we found that an elevated procalcitonin (PCT) level (p = 0.03), higher glucose level (p = 0.03), and lower total cholesterol (TC) level (p = 0.01) were associated with a higher likelihood of positive blood bacteriological culture. Additionally, an increased PCT level (p = 0.02) and lower TC level (p < 0.01) were associated with an elevated risk of septic shock. Furthermore, a higher PCT level (p < 0.01) was associated with a higher probability of ICU admission.

Conclusion: In patients with PLA caused by Klebsiella pneumoniae, the PCT, glucose, and TC levels were found to be associated with positive blood culture, septic shock, and ICU admission.

查看原文本刊更多论文

肺炎克雷伯氏菌引起化脓性肝脓肿的预后风险因素。

背景：由肺炎克雷伯氏菌引起的化脓性肝脓肿（PLA）的严重程度各不相同，而且有几种危险因素会导致PLA出现器官功能障碍。然而，迄今为止很少有研究探讨临床严重程度的最常见风险因素：我们对 2013 年 2 月至 2022 年 12 月间由肺炎克雷伯氏菌引起的 PLA 患者进行了研究。我们使用逻辑回归分析，试图找出与血培养阳性、脓毒性休克和入住重症监护病房（ICU）相关的因素：在纳入 200 名患者后，我们发现降钙素原 (PCT) 水平升高（p = 0.03）、葡萄糖水平升高（p = 0.03）和总胆固醇 (TC) 水平降低（p = 0.01）与血液细菌培养阳性的可能性较高有关。此外，PCT 水平升高（P = 0.02）和 TC 水平降低（P = 0.01）也与血液细菌培养呈阳性的可能性增加有关：在由肺炎克雷伯氏菌引起的 PLA 患者中，PCT、血糖和 TC 水平与血培养阳性、脓毒性休克和入住重症监护病房有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

BMC Gastroenterology 医学-胃肠肝病学

CiteScore

4.20

自引率

0.00%

发文量

465

审稿时长

6 months

期刊介绍： BMC Gastroenterology is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of gastrointestinal and hepatobiliary disorders, as well as related molecular genetics, pathophysiology, and epidemiology.