Youhan Liu, Wen Ma, Xuewen Tian, Qinglu Wang, Xin Lu, Ying Luo, Jun Xv
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引用次数: 0
Abstract
Interleukin-15 (IL-15) was identified in 1994 as a T-cell growth factor with the capability to mimic the functions of IL-2. IL-15 engages with the IL-15Rα subunit expressed on the surface of antigen-presenting cells (APCs) and, through a trans-presentation mechanism, activates the IL-2/IL-15Rβγ complex receptor on the surface of natural killer (NK) cells and CD8+ T cells. This interaction initiates a cascade of downstream signaling pathways, playing a pivotal role in the activation, proliferation, and anti-apoptotic processes in NK cells, CD8+ T cells, and B cells. It provides a substantial theoretical foundation and potential therapeutic targets for tumor immunotherapy. Whether through active or passive immunotherapeutic strategies, IL-15 has emerged as a critical molecule for stimulating anti-tumor cell proliferation.
白细胞介素-15（IL-15）于 1994 年被确认为一种 T 细胞生长因子，具有模仿 IL-2 的功能。IL-15 与抗原呈递细胞（APCs）表面表达的 IL-15Rα 亚基结合，并通过转呈机制激活自然杀伤（NK）细胞和 CD8+ T 细胞表面的 IL-2/IL-15Rβγ 复合受体。这种相互作用启动了一连串的下游信号通路，在 NK 细胞、CD8+ T 细胞和 B 细胞的活化、增殖和抗凋亡过程中发挥了关键作用。它为肿瘤免疫疗法提供了坚实的理论基础和潜在的治疗靶点。无论是通过主动还是被动免疫治疗策略，IL-15 都已成为刺激抗肿瘤细胞增殖的关键分子。
期刊介绍：
Formerly: Current Medicinal Chemistry - Anti-Cancer Agents.
Anti-Cancer Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of anti-cancer agents.
Each issue contains a series of timely in-depth reviews and guest edited issues written by leaders in the field covering a range of current topics in cancer medicinal chemistry. The journal only considers high quality research papers for publication.
Anti-Cancer Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in cancer drug discovery.
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