Estimating the viscoelastic anisotropy of human skin through high-frequency ultrasound elastography

IF 3.2 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Medical physics Pub Date : 2024-09-03 DOI:10.1002/mp.17372

Yu-Chen Wu, Guo-Xuan Xu, Chien Chen, Yi-Hsiang Chuang, Chih-Chung Huang

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引用次数: 0

Abstract

Background

The skin is the largest organ of the human body and serves distinct functions in protecting the body. The viscoelastic properties of the skin play a key role in supporting the skin-healing process, also it may be changed due to some skin diseases.

Propose

In this study, high-frequency ultrasound (HFUS) elastography based on a Lamb wave model was used to noninvasively assess the viscoelastic anisotropy of human skin.

Method

Elastic waves were generated through an external vibrator, and the wave propagation velocity was measured through 40 MHz ultrafast HFUS imaging. Through the use of a thin-layer gelatin phantom, HFUS elastography was verified to produce highly accurate estimates of elasticity and viscosity. In a human study involving five volunteers, viscoelastic anisotropy was assessed by rotating an ultrasound transducer 360°.

Results

An oval-shaped pattern in the elasticity of human forearm skin was identified, indicating the high elastic anisotropy of skin; the average elastic moduli were 24.90 ± 6.63 and 13.64 ± 2.67 kPa along and across the collagen fiber orientation, respectively. The average viscosity of all the recruited volunteers was 3.23 ± 0.93 Pa·s.

Conclusions

Although the examined skin exhibited elastic anisotropy, no evident viscosity anisotropy was observed.

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通过高频超声弹性成像估算人体皮肤的粘弹性各向异性。

背景：皮肤是人体最大的器官，具有保护身体的独特功能。本研究采用基于 Lamb 波模型的高频超声（HFUS）弹性成像技术，对人体皮肤的粘弹性各向异性进行无创评估：方法：通过外部振动器产生弹性波，并通过 40 MHz 超快 HFUS 成像测量波的传播速度。通过使用薄层明胶模型，验证了高频超声弹性成像技术能高度准确地估计弹性和粘度。在一项涉及五名志愿者的人体研究中，通过将超声换能器旋转 360°，对粘弹性各向异性进行了评估：结果：人体前臂皮肤的弹性呈椭圆形，表明皮肤的弹性各向异性较高；沿胶原纤维方向和横向的平均弹性模量分别为 24.90 ± 6.63 和 13.64 ± 2.67 kPa。所有受试志愿者的平均粘度为 3.23 ± 0.93 Pa-s：结论：虽然受检皮肤表现出弹性各向异性，但未观察到明显的粘度各向异性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medical physics 医学-核医学

CiteScore

6.80

自引率

15.80%

发文量

660

审稿时长

1.7 months

期刊介绍： Medical Physics publishes original, high impact physics, imaging science, and engineering research that advances patient diagnosis and therapy through contributions in 1) Basic science developments with high potential for clinical translation 2) Clinical applications of cutting edge engineering and physics innovations 3) Broadly applicable and innovative clinical physics developments Medical Physics is a journal of global scope and reach. By publishing in Medical Physics your research will reach an international, multidisciplinary audience including practicing medical physicists as well as physics- and engineering based translational scientists. We work closely with authors of promising articles to improve their quality.