Assessing the effects of spontaneous intracranial hypotension on quality of life, work ability and disability.

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Ali Kapan, Thomas Waldhör, Christian Wöber
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引用次数: 0

Abstract

Background: Spontaneous intracranial hypotension (SIH), characterized by headaches due to cerebrospinal fluid leaks or low pressure, is a challenging condition to diagnose and treat and affects the quality of life.

Methods: An 8‑week online survey was conducted to assess the impact of SIH on symptoms, sociodemographics and quality of life. The cohort was comprised of patients who had a self-reported diagnosis of SIH and were divided into two groups: those with radiological evidence of SIH and those with clinical suspicion but no radiological evidence. Mental health and disability were evaluated using the Depression, Anxiety and Stress Scale-21 (DASS-21) and the Henry Ford Hospital Headache Disability Inventory (HDI).

Results: A total of 86 participants were included in the study, 59 with radiological evidence and 27 without. Most participants were female (84.9%) with a mean age of 44.8 years. Orthostatic headache was more common in participants without radiological evidence (74.1% vs. 42.4%). The severity in those with radiological evidence was 27.1% mild, 27.1% moderate, 30.5% severe and 15.3% extremely severe, while those without had 7.4% mild, 18.5% moderate, 63.0% severe and 11.1% extremely severe headaches. Mental health assessment using the DASS-21 scale showed that 77.9% of all participants reported signs of depression, 96.5% reported anxiety and 89.5% reported stress. The HDI showed 2.3% total disability, 40.7% severe, 19.8% moderate and 37.2% mild. The impact on employment was significant: 15.1% were able to work full-time, 48.8% part-time, 30.2% were unable to work and 5.8% retired early due to SIH.

Conclusion: The study demonstrates the broad impact of SIH affecting physical health, mental well-being, and socioeconomic status, and calls for multifaceted and robust management approaches to address its complex effects on patients.

Abstract Image

评估自发性颅内低血压对生活质量、工作能力和残疾的影响。
背景:自发性颅内压过低(SIH)的特点是脑脊液漏或脑脊液压力过低导致头痛,是一种难以诊断和治疗并影响生活质量的疾病:我们开展了一项为期 8 周的在线调查,以评估 SIH 对症状、社会人口学和生活质量的影响。调查对象包括自述确诊为 SIH 的患者,并将其分为两组:有 SIH 影像学证据的患者和有临床怀疑但无影像学证据的患者。研究人员使用抑郁、焦虑和压力量表-21(DASS-21)和亨利福特医院头痛残疾量表(HDI)对患者的心理健康和残疾情况进行了评估:共有 86 人参与了研究,其中 59 人有放射学证据,27 人无放射学证据。大多数参与者为女性(84.9%),平均年龄为 44.8 岁。在没有放射证据的参与者中,直立性头痛更为常见(74.1% 对 42.4%)。有放射证据者头痛的严重程度为:轻度 27.1%、中度 27.1%、重度 30.5%、极重度 15.3%,而无放射证据者头痛的严重程度为:轻度 7.4%、中度 18.5%、重度 63.0%、极重度 11.1%。使用 DASS-21 量表进行的心理健康评估显示,77.9% 的参与者报告有抑郁迹象,96.5% 报告有焦虑,89.5% 报告有压力。人类发展指数显示,2.3%的人完全残疾,40.7%的人重度残疾,19.8%的人中度残疾,37.2%的人轻度残疾。SIH对就业的影响很大:15.1%的人可以全职工作,48.8%的人可以兼职工作,30.2%的人无法工作,5.8%的人提前退休:这项研究表明,SIH 对身体健康、心理健康和社会经济地位有着广泛的影响,因此需要采取多方面和强有力的管理方法来应对其对患者的复杂影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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