Epidemiology and genetic characterization of human parainfluenza virus-1 infection in pediatric patients from Hangzhou China, 2021-2022.

IF 4 3区医学 Q2 VIROLOGY

Virology Journal Pub Date : 2024-09-02 DOI:10.1186/s12985-024-02479-8

Ya-Jun Guo, Jian Sun, Ya-Lin Li, Qin-Rui Lai, Lin Li, Hang-Yu Zhou, Wei Li

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引用次数: 0

Abstract

Background: Human parainfluenza virus-1 (HPIV-1) is a notable pathogen instigating acute respiratory tract infections in children. The article is to elucidate the epidemiological and genetic characteristics of HPIV-1 circulating in Hangzhou during the period of 2021-2022.

Methods: A cohort of 2360 nasopharyngeal swabs were amassed and subsequently examined via RT-PCR, with HPIV-1 positive samples undergoing P gene sequencing.

Results: The highest HPIV-1 infection rates were found in children aged between 3 and 6 years. A pronounced positive rate persisted through the latter half of 2021, with a notable decline observed in the initial half of 2022. All HPIV-1 strains could be clustered into 2 groups: Cluster 1, with strains similar to those found in Japan (LC764865, LC764864), and Cluster 2, with strains similar to the Beijing strain (MW575643).

Conclusion: In conclusion, our study contributes to the comprehensive data on the epidemiological and genetic characteristics of HPIV-1 in pediatric patients from Hangzhou, post the COVID-19 peak.

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2021-2022 年中国杭州儿童感染人类副流感病毒-1 的流行病学和基因特征。

背景：人副流感病毒-1（HPIV-1）是引起儿童急性呼吸道感染的重要病原体。本文旨在阐明 2021-2022 年期间杭州流行的 HPIV-1 的流行病学和遗传学特征：方法：收集了2360份鼻咽拭子，随后通过RT-PCR进行检测，并对HPIV-1阳性样本进行P基因测序：结果：3 至 6 岁儿童的 HPIV-1 感染率最高。明显的阳性率持续到 2021 年下半年，2022 年上半年出现明显下降。所有 HPIV-1 株系可分为两组：第 1 组是与日本发现的菌株（LC764865、LC764864）相似的菌株，第 2 组是与北京菌株（MW575643）相似的菌株：总之，我们的研究有助于全面了解 COVID-19 高峰后杭州儿童患者中 HPIV-1 的流行病学和遗传学特征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Virology Journal 医学-病毒学

CiteScore

7.40

自引率

2.10%

发文量

186

审稿时长

1 months

期刊介绍： Virology Journal is an open access, peer reviewed journal that considers articles on all aspects of virology, including research on the viruses of animals, plants and microbes. The journal welcomes basic research as well as pre-clinical and clinical studies of novel diagnostic tools, vaccines and anti-viral therapies. The Editorial policy of Virology Journal is to publish all research which is assessed by peer reviewers to be a coherent and sound addition to the scientific literature, and puts less emphasis on interest levels or perceived impact.