Preventive and reparative effects of low-level laser therapy on orthodontically induced inflammatory root resorption-An animal study.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-09-03 DOI:10.1111/ocr.12853

Bowen Xu, Rina Du, Linna Bai, Kai Yang

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引用次数: 0

Abstract

Background: Orthodontically induced inflammatory root resorption (OIIRR) is one of the most important side effects of orthodontic treatment. Low-level laser therapy (LLLT) is a useful way to reduce the orthodontic treatment duration and may have some effect on preventing and repairing OIIRR. However, the specific effects of LLLT on OIIRR remain unknown.

Objective: Our research aimed to evaluate the Dentin Sialophosphoprotein (DSPP) expression level and root resorption volume during treatment and retention to explore the role of LLLT in preventing and repairing OIIRR.

Methods: Thirty-seven 6-week-old male Sprague-Dawley rats were selected to establish an OIIRR model; the rats were divided into Group B (blank), Group F (force), Group F(LLLT) (force and LLLT), Group F+R (force and retention) and Group F+R(LLLT) (force, retention and LLLT). The root resorption volume of the distal buccal root and mesial root in the maxillary left first molar was calculated by micro-CT, and the DSPP expression level on the compression side of the periodontal ligament was analysed by immunohistochemical staining.

Results: The resorption volume in Group F was greater than that in Group F(LLLT). For the mesial root, the volume in Group F was greater than that in Groups F+R and F+R(LLLT). For the distal buccal root, the volume in Groups F and F+R was greater than that in Group F+R(LLLT). The DSPP level in Group F(LLLT) was greater than that in Group F and there was no difference between Groups F+R and F+R(LLLT).

Conclusions: LLLT has a certain preventive effect and a limited reparative effect on OIIRR in rats.

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低强度激光疗法对正畸引起的炎性牙根吸收的预防和修复作用--一项动物研究。

背景：正畸诱发的炎性牙根吸收（OIIRR）是正畸治疗最重要的副作用之一。低强度激光疗法（LLLT）是缩短正畸治疗时间的有效方法，并可能对预防和修复 OIIRR 有一定作用。然而，LLLT 对 OIIRR 的具体影响仍然未知：我们的研究旨在评估治疗和保持期间牙本质鞘磷蛋白（DSPP）的表达水平和牙根吸收量，以探讨 LLLT 在预防和修复 OIIRR 中的作用：方法：选择37只6周龄雄性Sprague-Dawley大鼠建立OIIRR模型，将其分为B组（空白）、F组（用力）、F(LLLT)组（用力和LLLT）、F+R组（用力和保留）和F+R(LLLT)组（用力、保留和LLLT）。通过显微 CT 计算上颌左侧第一磨牙远端颊侧根和中侧根的牙根吸收量，并通过免疫组化染色分析牙周韧带受压侧的 DSPP 表达水平：结果：F组的吸收量大于F（LLLT）组。就中牙根而言，F 组的吸收量大于 F+R 组和 F+R（LLLT）组。就颊根远端而言，F 组和 F+R 组的体积大于 F+R（LLLT）组。F 组（LLLT）的 DSPP 水平高于 F 组，F+R 组和 F+R（LLLT）组之间没有差异：结论：LLLT 对大鼠 OIIRR 有一定的预防作用和有限的修复作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464