CHIKV infection drives shifts in the gastrointestinal microbiome and metabolites in rhesus monkeys.

IF 13.8 1区生物学 Q1 MICROBIOLOGY

Microbiome Pub Date : 2024-08-30 DOI:10.1186/s40168-024-01895-w

Hongyu Chen, Jiandong Shi, Cong Tang, Jingwen Xu, Bai Li, Junbin Wang, Yanan Zhou, Yun Yang, Hao Yang, Qing Huang, Wenhai Yu, Haixuan Wang, Daoju Wu, Yunzhang Hu, Hongning Zhou, Qingming Sun, Shuaiyao Lu

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引用次数: 0

Abstract

Background: Many studies have demonstrated the association between intestinal microbiota and joint diseases. The "gut-joint axis" also has potential roles in chikungunya virus (CHIKV) infection. Pro-inflammatory arthritis after CHIKV infection might disrupt host homeostasis and lead to dysbacteriosis. This study investigated the characteristics of fecal and gut microbiota, intestinal metabolites, and the changes in gene regulation of intestinal tissues after CHIKV infection using multi-omics analysis to explore the involvement of gut microbiota in the pathogenesis of CHIKV infection.

Results: CHIKV infection increases the systemic burden of inflammation in the GI system of infected animals. Moreover, infection-induced alterations in GI microbiota and metabolites may be indirectly involved in the modulation of GI and bone inflammation after CHIKV infection, including the modulation of inflammasomes and interleukin-17 inflammatory cytokine levels.

Conclusion: Our results suggest that the GI tract and its microbes are involved in the modulation of CHIKV infection, which could serve as an indicator for the adjuvant treatment of CHIKV infection. Video Abstract.

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CHIKV感染导致恒河猴胃肠道微生物组和代谢物发生变化。

背景：许多研究已证明肠道微生物群与关节疾病之间存在关联。肠道-关节轴 "在基孔肯雅病毒（CHIKV）感染中也有潜在作用。基孔肯雅病毒感染后的促炎性关节炎可能会破坏宿主体内平衡，并导致菌群失调。本研究利用多组学分析方法研究了CHIKV感染后粪便和肠道微生物群的特征、肠道代谢产物以及肠道组织基因调控的变化，以探讨肠道微生物群在CHIKV感染发病机制中的参与：结果：CHIKV感染增加了感染动物肠道系统的炎症负担。此外，感染引起的消化道微生物群和代谢产物的改变可能间接参与了CHIKV感染后消化道和骨骼炎症的调节，包括炎症小体和白细胞介素-17炎症细胞因子水平的调节：我们的研究结果表明，消化道及其微生物参与了对CHIKV感染的调节，可作为CHIKV感染辅助治疗的指标。视频摘要

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来源期刊

Microbiome MICROBIOLOGY-

CiteScore

21.90

自引率

2.60%

发文量

198

审稿时长

4 weeks

期刊介绍： Microbiome is a journal that focuses on studies of microbiomes in humans, animals, plants, and the environment. It covers both natural and manipulated microbiomes, such as those in agriculture. The journal is interested in research that uses meta-omics approaches or novel bioinformatics tools and emphasizes the community/host interaction and structure-function relationship within the microbiome. Studies that go beyond descriptive omics surveys and include experimental or theoretical approaches will be considered for publication. The journal also encourages research that establishes cause and effect relationships and supports proposed microbiome functions. However, studies of individual microbial isolates/species without exploring their impact on the host or the complex microbiome structures and functions will not be considered for publication. Microbiome is indexed in BIOSIS, Current Contents, DOAJ, Embase, MEDLINE, PubMed, PubMed Central, and Science Citations Index Expanded.