Update on JNK inhibitor patents: 2015 to present.

IF 5.4 2区 医学 Q1 CHEMISTRY, MEDICINAL
Expert Opinion on Therapeutic Patents Pub Date : 2024-10-01 Epub Date: 2024-09-08 DOI:10.1080/13543776.2024.2400167
Guotai Feng, Xiao Yang, Wen Shuai, Guan Wang, Liang Ouyang
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引用次数: 0

Abstract

Introduction: c-Jun N-terminal kinase (JNK) regulates various biological processes through the phosphorylation cascade and is closely associated with numerous diseases, including inflammation, cardiovascular diseases, and neurological disorders. Therefore, JNKs have emerged as potential targets for disease treatment.

Areas covered: This review compiles the patents and literatures concerning JNK inhibitors through retrieving relevant information from the SciFinder, Google Patents databases, and PubMed from 2015 to the present. It summarizes the structure-activity relationship (SAR) and biological activity profiles of JNK inhibitors, offering valuable perspectives on their potential therapeutic applications.

Expert opinion: The JNK kinase serves as a novel target for the treatment of neurodegenerative disorders, pulmonary fibrosis, and other illnesses. A variety of small-molecule inhibitors targeting JNKs have demonstrated promising therapeutic potential in preclinical studies, which act upon JNK kinases via distinct mechanisms, encompassing traditional ATP competitive inhibition, covalent inhibition, and bidentate inhibition. Among them, several JNK inhibitors from PregLem SA, Celegene SA, and Xigen SA have accomplished the early stage of clinical trials, and their results will guide the development and indications of future JNK inhibitors.

JNK 抑制剂专利更新:2015 年至今。
导言:c-Jun N-末端激酶(JNK)通过磷酸化级联调节各种生物过程,并与许多疾病密切相关,包括炎症、心血管疾病和神经系统疾病。因此,JNKs 已成为治疗疾病的潜在靶点:本综述通过从 SciFinder、Google Patents 数据库和 PubMed 中检索 2015 年至今有关 JNK 抑制剂的相关信息,汇编了有关 JNK 抑制剂的专利和文献。它总结了JNK抑制剂的结构-活性关系(SAR)和生物活性特征,为其潜在的治疗应用提供了有价值的观点:JNK激酶是治疗神经退行性疾病、肺纤维化和其他疾病的新靶点。在临床前研究中,多种以JNK为靶点的小分子抑制剂已显示出良好的治疗潜力,它们通过不同的机制作用于JNK激酶,包括传统的ATP竞争性抑制、共价抑制和双叉抑制。其中,PregLem SA、Celegene SA 和 Xigen SA 的几种 JNK 抑制剂已完成早期临床试验,其结果将指导未来 JNK 抑制剂的开发和适应症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
12.10
自引率
1.50%
发文量
50
审稿时长
6-12 weeks
期刊介绍: Expert Opinion on Therapeutic Patents (ISSN 1354-3776 [print], 1744-7674 [electronic]) is a MEDLINE-indexed, peer-reviewed, international journal publishing review articles on recent pharmaceutical patent claims, providing expert opinion the scope for future development, in the context of the scientific literature. The Editors welcome: Reviews covering recent patent claims on compounds or applications with therapeutic potential, including biotherapeutics and small-molecule agents with specific molecular targets; and patenting trends in a particular therapeutic area Patent Evaluations examining the aims and chemical and biological claims of individual patents Perspectives on issues relating to intellectual property The audience consists of scientists, managers and decision-makers in the pharmaceutical industry and others closely involved in R&D Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days.
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