An Analysis of the Radiosensitiser Applications in the Biomedical Field.

IF 1.5 4区医学 Q3 PHARMACOLOGY & PHARMACY

Current radiopharmaceuticals Pub Date : 2024-09-02 DOI:10.2174/0118744710269842240825160247

Teng Sheng Lim, Irman Abdul Rahman, Aminah Umar, Norsyahidah Mohd Hidzir, Kenton Paul Arkill, Razinah Sharif, Mohd Anuar Jonet, Hur Munawar Kabir Mohd, Faizal Mohamed

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引用次数: 0

Abstract

Background: Various types of radiosensitisers have been introduced from the past until the present day for applications in the biomedical field. However, there is a lack of understanding and comparison between the various parameters introduced in addition to a lack of consensus among researchers on the optimal radiosensitiser for applications in the biomedical field.

Objective: This review aimed to investigate the usage of radiosensitisers in the biomedical field, determine their important parameters, and suggest radiosensitisers with potential among the analysed radiosensitisers.

Results and conclusion: This review has discussed several parameters for radiosensitisers, including median lethal dose, cell survival, tumour size, cell viability, Dose Enhancement Factor (DEF), Reactive Oxygen Species (ROS) concentration, radiosensitiser production complexity, radiosensitiser administration technique, and radiosensitiser toxicity. General trends regarding the development of radiosensitisers, including the types, effectiveness, and their production complexity, have also been discussed within this review article.

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分析放射增敏剂在生物医学领域的应用。

背景：从古至今，在生物医学领域应用的放射增感剂种类繁多。然而，除了研究人员对生物医学领域应用的最佳放射增敏剂缺乏共识外，对所引入的各种参数也缺乏了解和比较：本综述旨在调查放射增敏剂在生物医学领域的使用情况，确定其重要参数，并在分析的放射增敏剂中推荐具有潜力的放射增敏剂：本综述讨论了放射增敏剂的几个参数，包括中位致死剂量、细胞存活率、肿瘤大小、细胞活力、剂量增强因子（DEF）、活性氧（ROS）浓度、放射增敏剂生产复杂性、放射增敏剂给药技术和放射增敏剂毒性。本综述文章还讨论了放射增敏剂发展的总体趋势，包括类型、有效性及其生产复杂性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current radiopharmaceuticals PHARMACOLOGY & PHARMACY-

CiteScore

3.20

自引率

4.30%

发文量