Cholesterol to saturated fat index (CSI), metabolic parameters and inflammatory factors among obese individuals.

IF 2.8 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM
Mehrnaz Shakarami, Burhan Abdullah Zaman, Abdullah Sedaghat, Huda Muhammad Abbas Qassem, Yamamah Abas Zedann, Nashat Ali Soud, Mohaned Adil, Shabnam Shirvani, Naghmeh Nikbin
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Abstract

Background: The role of dietary fat quality in promotion of cardiovascular diseases is studies before. However, the results are inconsistent. Recently, cholesterol to saturated fatty acid index (CSI) is suggested as a novel indicator of the atherogenicity and thrombogenicity potential of a diet. However, due to limited number of studies, in the current cross-sectional study, we aimed to evaluate the role of CSI in metabolic and inflammatory response among obese individuals.

Methods: In the current cross-sectional study 488 obese individuals aged 18-50 years old were involved in volunteer based invitation from outpatient obesity clinics. Subjects underwent anthropometric assays including weight, height, waist circumference (WC) and body composition and their fasting blood sample were obtained for biochemical assessments including blood sugar, serum lipids, hs-CRP and IL-6 concentrations by commercial kits. Physical activity was also assessed by short form of international physical activity questionnaire (IPAQ).

Results: According to our results, being at the top tetile of CSI was associated with higher anthropometric indices including weight, height, WC, FFM, and basal metabolic rate (BMR) compared with those at the lowest tertile (P < 0.05). Similarly, those at the highest category of CSI had significantly higher levels of serum glucose and hs-CRP both in crude and adjusted models in ANCOVA and in multinomial logistic regression models (P < 0.05).

Conclusion: In the current study, for the first time, we identified the possible triggering role of dietary cholesterol to saturated fat index in increasing serum glucose and hs-CRP levels. due to cross-sectional design of the current study, causal inference is impossible. Further studies will help for better scientific justification.

肥胖者的胆固醇饱和脂肪指数(CSI)、代谢参数和炎症因素。
背景:关于膳食脂肪质量在促进心血管疾病中的作用的研究以前就有。然而,研究结果并不一致。最近,胆固醇-饱和脂肪酸指数(CSI)被认为是衡量膳食致动脉粥样硬化性和血栓形成可能性的新指标。然而,由于研究数量有限,在本次横断面研究中,我们旨在评估 CSI 在肥胖者代谢和炎症反应中的作用:在本次横断面研究中,我们邀请了 488 名年龄在 18-50 岁之间的肥胖者作为志愿者,他们来自肥胖症门诊。受试者接受了人体测量测定,包括体重、身高、腰围(WC)和身体成分,并通过商用试剂盒采集空腹血样进行生化评估,包括血糖、血脂、hs-CRP 和 IL-6 浓度。此外,还通过国际体力活动调查问卷(IPAQ)简表对体力活动进行了评估:结果:根据我们的研究结果,与最低三分位数的人相比,处于 CSI 最高四分位数的人与较高的人体测量指数相关,包括体重、身高、腹围、FFM 和基础代谢率(BMR)(P 结论:CSI 最高四分位数的人与较高的人体测量指数相关,包括体重、身高、腹围、FFM 和基础代谢率(BMR):在本研究中,我们首次发现了膳食胆固醇-饱和脂肪指数在增加血清葡萄糖和 hs-CRP 水平中可能起到的诱发作用。进一步的研究将有助于更好地进行科学论证。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
BMC Endocrine Disorders
BMC Endocrine Disorders ENDOCRINOLOGY & METABOLISM-
CiteScore
4.40
自引率
0.00%
发文量
280
审稿时长
>12 weeks
期刊介绍: BMC Endocrine Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of endocrine disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
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