Engineered human heart tissue reveals pathogenicity of autoantibodies in systemic lupus erythematosus

Abstract

IgG autoantibodies from patients with systemic lupus erythematosus (SLE) and systolic dysfunction directly affect engineered human heart tissue, altering cellular composition, respiration and calcium handling. Four pathogenic autoantibodies that may target cardiomyocyte function provide insights into myocardial injury in SLE.