TSH is independently associated with remnant cholesterol in euthyroid adults: a cross-sectional study based on 29,708 individuals.

IF 2.4 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Hormones-International Journal of Endocrinology and Metabolism Pub Date : 2024-08-31 DOI:10.1007/s42000-024-00596-1

Mengge Yang, Ying Wei, Ying Wang, Jia Liu, Guang Wang

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Abstract

Purpose: The study aims to investigate the relationship between thyroid-stimulating hormone (TSH) and remnant cholesterol (RC) in euthyroid adults.

Methods: The adults who were recruited for the study had undergone physical examination at Beijing Chao-Yang Hospital. High RC levels were defined as the upper quartile of RC levels in males and females, respectively. The relationship between TSH and RC was assessed using the logistic and linear regression models.

Results: A total of 29,708 adults (14,347 males and 15,361 females) were enrolled in this study. RC ≥ 0.77 mmol/L in males and RC ≥ 0.60 mmol/L in females were defined as high RC levels. With increasing serum TSH levels, the percentage of adults with high RC levels increased. The odds ratios (ORs (95% confidence intervals (CIs)) for high RC levels increased as TSH quartiles (Q) rose after full adjustments [males: Q2 1.11 (1.00-1.24), P < 0.05; Q3 1.03 (0.92-1.15), P > 0.05; Q4 1.25 (1.12-1.40), P < 0.001; and females: Q2 1.07 (0.96-1.20), P > 0.05; Q3 1.17 (1.05-1.31), P < 0.01, Q4 1.33 (1.20-1.48), P < 0.001, all P for trend < 0.001], using Q1 as the reference.

Conclusion: Higher TSH levels were independently associated with higher RC levels in euthyroid adults, this underscoring the significance of regulating TSH levels appropriately.

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促甲状腺激素与甲状腺功能正常的成年人体内残余胆固醇的关系：一项基于 29 708 人的横断面研究。

目的：本研究旨在探讨甲状腺功能正常的成年人体内促甲状腺激素（TSH）与残余胆固醇（RC）之间的关系：研究招募的成年人均在北京朝阳医院接受过体检。RC水平高分别定义为男性和女性RC水平的上四分位数。采用逻辑和线性回归模型评估 TSH 与 RC 之间的关系：共有 29 708 名成人（男性 14 347 人，女性 15 361 人）参与了这项研究。男性 RC ≥ 0.77 mmol/L、女性 RC ≥ 0.60 mmol/L 被定义为高 RC 水平。随着血清 TSH 水平的升高，成人中 RC 水平高的比例也在增加。经充分调整后，高 RC 水平的几率比（ORs）（95% 置信区间（CIs））随着 TSH 四分位数（Q）的增加而增加[男性：Q2 1.11 (1.00-1.24)，P 0.05；Q4 1.25 (1.12-1.40)，P 0.05；Q3 1.17 (1.05-1.31)，P 结论：在甲状腺功能正常的成年人中，较高的促甲状腺激素水平与较高的 RC 水平独立相关，这凸显了适当调节促甲状腺激素水平的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hormones-International Journal of Endocrinology and Metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

5.90

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Hormones-International Journal of Endocrinology and Metabolism is an international journal published quarterly with an international editorial board aiming at providing a forum covering all fields of endocrinology and metabolic disorders such as disruption of glucose homeostasis (diabetes mellitus), impaired homeostasis of plasma lipids (dyslipidemia), the disorder of bone metabolism (osteoporosis), disturbances of endocrine function and reproductive capacity of women and men. Hormones-International Journal of Endocrinology and Metabolism particularly encourages clinical, translational and basic science submissions in the areas of endocrine cancers, nutrition, obesity and metabolic disorders, quality of life of endocrine diseases, epidemiology of endocrine and metabolic disorders.