Revolutionizing Immunotherapy: Unveiling New Horizons, Confronting Challenges, and Navigating Therapeutic Frontiers in CAR-T Cell-Based Gene Therapies.

IF 6.2 Q1 IMMUNOLOGY
ImmunoTargets and Therapy Pub Date : 2024-08-27 eCollection Date: 2024-01-01 DOI:10.2147/ITT.S474659
Shivani Srivastava, Anuradha Tyagi, Vishakha Anand Pawar, Nawaid Hussain Khan, Kavita Arora, Chaitenya Verma, Vinay Kumar
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引用次数: 0

Abstract

The CAR-T cell therapy has marked the dawn of new era in the cancer therapeutics and cell engineering techniques. The review emphasizes on the challenges that obstruct the therapeutic efficiency caused by cell toxicities, immunosuppressive tumor environment, and decreased T cell infiltration. In the interest of achieving the overall survival (OS) and event-free survival (EFS) of patients, the conceptual background of potential target selection and various CAR-T cell design techniques are described which can minimize the off-target effects, reduce toxicity, and thus increase the resilience of CAR-T cell treatment in the haematological malignancies as well as in solid tumors. Furthermore, it delves into cutting-edge technologies like gene editing and synthetic biology, providing new opportunities to enhance the functionality of CAR-T cells and overcome mechanisms of immune evasion. This review provides a comprehensive understanding of the complex and diverse aspects of CAR-T cell-based gene treatments, including both scientific and clinical aspects. By effectively addressing the obstacles and utilizing the capabilities of cutting-edge technology, CAR-T cell therapy shows potential in fundamentally changing immunotherapy and reshaping the approach to cancer treatment.

免疫疗法的革命:揭开基于 CAR-T 细胞基因疗法的新视野、应对挑战并引领治疗前沿。
CAR-T 细胞疗法标志着癌症疗法和细胞工程技术新时代的到来。综述强调了细胞毒性、免疫抑制性肿瘤环境和 T 细胞浸润减少等阻碍治疗效率的挑战。为了实现患者的总生存期(OS)和无事件生存期(EFS),文章介绍了潜在靶点选择的概念背景和各种 CAR-T 细胞设计技术,这些技术可以最大限度地减少脱靶效应、降低毒性,从而提高 CAR-T 细胞治疗血液恶性肿瘤和实体瘤的疗效。此外,它还深入探讨了基因编辑和合成生物学等前沿技术,为增强 CAR-T 细胞的功能和克服免疫逃避机制提供了新的机遇。这篇综述全面介绍了基于 CAR-T 细胞的基因治疗的复杂性和多样性,包括科学和临床两个方面。通过有效解决障碍和利用尖端技术的能力,CAR-T 细胞疗法显示出从根本上改变免疫疗法和重塑癌症治疗方法的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
16.50
自引率
0.00%
发文量
7
审稿时长
16 weeks
期刊介绍: Immuno Targets and Therapy is an international, peer-reviewed open access journal focusing on the immunological basis of diseases, potential targets for immune based therapy and treatment protocols employed to improve patient management. Basic immunology and physiology of the immune system in health, and disease will be also covered.In addition, the journal will focus on the impact of management programs and new therapeutic agents and protocols on patient perspectives such as quality of life, adherence and satisfaction.
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