Pretreatment can alleviate programmed cell death in mesenchymal stem cells.

IF 3.6 3区 医学 Q3 CELL & TISSUE ENGINEERING
Xin-Xing Wan, Xi-Min Hu, Qi Zhang, Kun Xiong
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引用次数: 0

Abstract

In this editorial, we delved into the article titled "Cellular preconditioning and mesenchymal stem cell ferroptosis." This groundbreaking study underscores a pivotal discovery: Ferroptosis, a type of programmed cell death, drastically reduces the viability of donor mesenchymal stem cells (MSCs) after engraftment, thereby undermining the therapeutic value of cell-based therapies. Furthermore, the article proposes that by manipulating ferroptosis mechanisms through preconditioning, we can potentially enhance the survival rate and functionality of MSCs, ultimately amplifying their therapeutic potential. Given the crucial role ferroptosis plays in shaping the therapeutic outcomes of MSCs, we deem it imperative to further investigate the intricate interplay between programmed cell death and the therapeutic effectiveness of MSCs.

预处理可减轻间充质干细胞的程序性细胞死亡。
在这篇社论中,我们深入探讨了题为 "细胞预处理与间充质干细胞铁蛋白沉积 "的文章。这项突破性研究强调了一个关键发现:铁凋亡是一种程序性细胞死亡,可大幅降低供体间充质干细胞(MSCs)移植后的存活率,从而削弱细胞疗法的治疗价值。此外,文章还提出,通过预处理操纵铁突变机制,我们有可能提高间充质干细胞的存活率和功能,最终放大其治疗潜力。鉴于铁凋亡在塑造间充质干细胞治疗效果中的关键作用,我们认为有必要进一步研究程序性细胞死亡与间充质干细胞治疗效果之间错综复杂的相互作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
World journal of stem cells
World journal of stem cells Biochemistry, Genetics and Molecular Biology-Molecular Biology
CiteScore
7.80
自引率
4.90%
发文量
750
期刊介绍: The World Journal of Stem Cells (WJSC) is a leading academic journal devoted to reporting the latest, cutting-edge research progress and findings of basic research and clinical practice in the field of stem cells. It was launched on December 31, 2009 and is published monthly (12 issues annually) by BPG, the world''s leading professional clinical medical journal publishing company.
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