Causal association between 731 immunocyte phenotypes and liver cirrhosis: A bidirectional two-sample mendelian randomization analysis.

IF 2.5 Q2 GASTROENTEROLOGY & HEPATOLOGY
Ying Li, Xin Quan, Yang Tai, Yu-Tong Wu, Bo Wei, Hao Wu
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引用次数: 0

Abstract

Background: Liver cirrhosis is a progressive hepatic disease whose immunological basis has attracted increasing attention. However, it remains unclear whether a concrete causal association exists between immunocyte phenotypes and liver cirrhosis.

Aim: To explore the concrete causal relationships between immunocyte phenotypes and liver cirrhosis through a mendelian randomization (MR) study.

Methods: Data on 731 immunocyte phenotypes were obtained from genome-wide association studies. Liver cirrhosis data were derived from the Finn Gen dataset, which included 214403 individuals of European ancestry. We used inverse variable weighting as the primary analysis method to assess the causal relationship. Sensitivity analyses were conducted to evaluate heterogeneity and horizontal pleiotropy.

Results: The MR analysis demonstrated that 11 immune cell phenotypes have a positive association with liver cirrhosis [P < 0.05, odds ratio (OR) > 1] and that 9 immunocyte phenotypes were negatively correlated with liver cirrhosis (P < 0.05, OR < 1). Liver cirrhosis was positively linked to 9 immune cell phenotypes (P < 0.05, OR > 1) and negatively linked to 10 immune cell phenotypes (P < 0.05; OR < 1). None of these associations showed heterogeneity or horizontally pleiotropy (P > 0.05).

Conclusion: This bidirectional two-sample MR study demonstrated a concrete causal association between immunocyte phenotypes and liver cirrhosis. These findings offer new directions for the treatment of liver cirrhosis.

731 种免疫细胞表型与肝硬化之间的因果关系:双向双样本泯灭随机分析
背景:肝硬化是一种进行性肝病,其免疫学基础已引起越来越多的关注。目的:通过亡羊补牢随机化(MR)研究,探讨免疫细胞表型与肝硬化之间的具体因果关系:方法:从全基因组关联研究中获得731种免疫细胞表型的数据。肝硬化数据来自芬兰基因数据集,其中包括 214403 名欧洲血统的个体。我们使用反向变量加权作为主要分析方法来评估因果关系。我们还进行了敏感性分析,以评估异质性和水平多效性:MR分析表明,11种免疫细胞表型与肝硬化呈正相关[P<0.05,比值比(OR)>1],9种免疫细胞表型与肝硬化呈负相关(P<0.05,OR<1)。肝硬化与 9 种免疫细胞表型呈正相关(P < 0.05,OR > 1),与 10 种免疫细胞表型呈负相关(P < 0.05;OR < 1)。这些关联均未显示异质性或水平褶积性(P > 0.05):这项双向双样本磁共振研究证明了免疫细胞表型与肝硬化之间的具体因果关系。这些发现为肝硬化的治疗提供了新的方向。
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来源期刊
World Journal of Hepatology
World Journal of Hepatology GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
4.10
自引率
4.20%
发文量
172
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