A simplified model to understand the targeted disease-modifying anti-inflammatory drugs.

Q4 Medicine

Ugeskrift for laeger Pub Date : 2024-08-12 DOI:10.61409/V12230795

Tue Wenzel Kragstrup, Kristine Jagd Ottosen, Line Uhrenholt, Emil Barner Dalgaard

引用次数: 0

Abstract

This review presents a simplified model to understand better how disease-modifying anti-inflammatory drugs (DMAIDs) work in immune-mediated inflammatory diseases (IMIDs) with a focus on rheumatology, dermatology, and gastroenterology. In this model, IMIDs are listed on a spectrum from autoinflammatory to autoimmune characterised by the involvement of either mostly the innate or the adaptive immune system. DMAIDs specifically target these immune components and have shown efficacy in distinct IMIDs. DMAID classes include TNF blockers, IL-1 blockers, IL-6 receptor blockers, IL-17 blockers, IL-23 blockers, and janus kinase inhibitors.

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了解靶向疾病调节抗炎药物的简化模型。

本综述介绍了一个简化模型，以更好地理解改变病情抗炎药（DMAIDs）是如何在免疫介导的炎症性疾病（IMIDs）中发挥作用的，重点关注风湿病学、皮肤病学和胃肠病学。在这一模式中，IMIDs 可分为自身炎症性和自身免疫性两类，其特点是主要涉及先天性免疫系统或适应性免疫系统。DMAID 专门针对这些免疫成分，对不同的 IMID 具有疗效。DMAID 类药物包括 TNF 阻断剂、IL-1 阻断剂、IL-6 受体阻断剂、IL-17 阻断剂、IL-23 阻断剂和 janus 激酶抑制剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ugeskrift for laeger Medicine-Medicine (all)

CiteScore

0.20

自引率

0.00%

发文量

345

期刊介绍： The Ulster Medical Journal is an international general medical journal with contributions on all areas of medical and surgical specialties relevant to a general medical readership. It retains a focus on material relevant to the health of the Northern Ireland population. The Honorary Editor would welcome offers of papers for publication. Prospective authors are invited to read the notice to contributors.