An Exploratory Case-Control Study for Mitochondrial DNA G10398A in Bipolar I Disorder Patients with a Family History of Affective Disorders.

IF 0.8 Q3 MEDICINE, GENERAL & INTERNAL
Nigerian Postgraduate Medical Journal Pub Date : 2024-07-01 Epub Date: 2024-09-02 DOI:10.4103/npmj.npmj_119_24
Rajan Mishra, Rizwana Quraishi, Raman Deep, Raka Jain
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引用次数: 0

Abstract

Background: The mitochondrial DNA (mtDNA) G10398A polymorphism has been associated with bipolar disorder (BD). It leads to an amino acid substitution within NADH dehydrogenase subunit, thereby altering the mitochondrial complex I function. This exploratory case-control study assesses the association of mtDNA G10398A with the risk of BD and its relationship to clinical variables in Indian patients.

Methods: Cases met the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition diagnosis of BD-I in remission and had a family history of BD or recurrent unipolar disorder in biological relatives. The healthy controls (HC) had no known illness and were screened negative for Family Interview for Genetic Studies. Participants were assessed using Clinical Pro forma, NIMH-Life Chart Method and Alda lithium response scale. The mtDNA G10398A was assessed with real-time polymerase chain reaction using TaqMan assay.

Results: A total of 82 participants were recruited across cases and controls, with 42 patients (50% with maternal history) and 40 healthy individuals with similar demographic profiles. The mean age of onset was 25.16 (standard deviation [SD] 7.6) years, with illness for 11.59 years (SD: 7.18). Allele A was found in 50% of cases compared to 32.5% HC (odds ratio = 2.08; 95% confidence interval [CI]: 0.85-5.09). Findings remain non-significant for patients with maternal mood disorders (allele A: 38.9%; 21/42). Cases with allele G had significantly higher body mass index (BMI) (P = 0.008) than those with allele A.

Conclusion: The study adds information on mtDNA 10398A amongst Indian patient samples and healthy individuals. No significant group difference was found with respect to mtDNA G10398A. The positive association of allele G with higher BMI has potential clinical relevance that can be further investigated in larger samples.

一项关于有情感障碍家族史的双相情感障碍 I 患者线粒体 DNA G10398A 的探索性病例对照研究。
背景:线粒体 DNA(mtDNA)G10398A 多态性与双相情感障碍(BD)有关。该多态性导致 NADH 脱氢酶亚基中的一个氨基酸置换,从而改变了线粒体复合体 I 的功能。这项探索性病例对照研究评估了印度患者的 mtDNA G10398A 与躁狂症风险的关联及其与临床变量的关系:方法:病例符合《精神疾病诊断与统计手册》第五版关于BD-I缓解期的诊断,并有BD家族史或亲缘关系中存在复发性单相情感障碍。健康对照组(HC)没有已知的疾病,遗传学家庭访谈筛查结果为阴性。采用临床表格法、NIMH-生活图表法和阿尔达锂反应量表对参与者进行评估。使用 TaqMan 法进行实时聚合酶链反应,评估 mtDNA G10398A:共招募了 82 名病例和对照组参与者,其中 42 名患者(50% 有孕产史)和 40 名健康人具有相似的人口统计学特征。平均发病年龄为 25.16 岁(标准差 [SD] 7.6),患病时间为 11.59 年(标准差:7.18)。50%的病例发现了等位基因 A,而 32.5% 的 HC 发现了等位基因 A(几率比 = 2.08;95% 置信区间 [CI]:0.85-5.09)。母性情绪障碍患者的研究结果仍然不显著(等位基因 A:38.9%;21/42)。等位基因 G 的病例的体重指数(BMI)明显高于等位基因 A 的病例(P = 0.008):该研究增加了有关印度患者样本和健康人 mtDNA 10398A 的信息。在 mtDNA G10398A 方面没有发现明显的群体差异。等位基因 G 与较高体重指数的正相关具有潜在的临床意义,可在更大样本中进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Nigerian Postgraduate Medical Journal
Nigerian Postgraduate Medical Journal MEDICINE, GENERAL & INTERNAL-
CiteScore
1.90
自引率
0.00%
发文量
52
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