A Prospective Study on Perfusion MRI Changes in Intracranial Meningiomas Following Gamma Knife Therapy.

IF 0.9 3区医学 Q4 NEUROSCIENCES

Neurology India Pub Date : 2024-07-01 Epub Date: 2024-08-31 DOI:10.4103/neurol-india.NI_317_20

Bhoopendra Singh, Deepak Agrawal, Ajay Garg, Manmohan Singh, P S Chandra, Shashank S Kale

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引用次数: 0

Abstract

Background: Radiosurgery plays an important role as a treatment modality for intracranial meningiomas. Perfusion MR imaging can be performed by using arterial spin-labeling (ASL) which is a relatively new and advanced technique.

Objectives: To assess the changes in perfusion parameters on ASL perfusion MRI in intracranial meningioma after radiosurgery and correlate with histopathological grade of meningioma.

Materials and methods: In this Prospective study done at the our institute over a period of 20 months (Jan 2016-Aug 2017), patients with intracranial meningiomas had perfusion MRI with ASL sequence on GE Optima 450W®, 1.5T MRI (GE Medical Systems) prior to GKT and at 6 months after GKT were included in the study.

Results: Twenty-seven patients were included in this study. Mean cerebral blood flow (CBF) was higher in angiomatous meningiomas. Though mean values of average CBF, maximum, minimum, and SD derived from the ASL MR perfusion were relatively higher in post GKT group as compared to those obtained in pre-GKT but it was not clinically significant. Mean baseline volume of whole cohort was 5.71 cm3 and decreased significantly post GKT in a follow up of 6 months to 5.59 cm3 (P value 0.0018). On comparing volumes of primary and secondary group, volumes were not found be significantly decreased in primary group (P value = 0.1361), 0.1361), but significantly reduced in secondary group (7.13 vs 7.034 cm3) (P value of = 0.0038).

Conclusion: Our preliminary observations support ASL as a sensitive MRI sequence for the evaluation of meningioma perfusion patterns.

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伽玛刀治疗后颅内脑膜瘤灌注磁共振成像变化的前瞻性研究

背景：放射手术是治疗颅内脑膜瘤的一种重要方法。灌注磁共振成像可通过动脉自旋标记（ASL）进行，这是一种相对较新的先进技术：评估放射手术后颅内脑膜瘤的 ASL 灌注 MRI 灌注参数的变化，并与脑膜瘤的组织病理学分级相关联：在本研究所进行的这项为期20个月（2016年1月至2017年8月）的前瞻性研究中，颅内脑膜瘤患者在GKT前和GKT后6个月在GE Optima 450W®, 1.5T MRI（GE医疗系统公司）上进行了ASL序列的灌注MRI检查：本研究共纳入 27 名患者。血管瘤型脑膜瘤的平均脑血流量（CBF）较高。虽然从 ASL MR 灌注中得出的平均 CBF、最大值、最小值和 SD 的平均值在 GKT 后组相对高于 GKT 前组，但临床意义不大。整个组群的平均基线体积为 5.71 立方厘米，GKT 后随访 6 个月后明显降低至 5.59 立方厘米（P 值为 0.0018）。比较原发性组和继发性组的体积，发现原发性组的体积没有明显减少（P 值 = 0.1361），0.1361），但继发性组的体积明显减少（7.13 vs 7.034 cm3）（P 值 = 0.0038）：我们的初步观察结果支持 ASL 作为评估脑膜瘤灌注模式的灵敏 MRI 序列。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurology India 医学-神经科学

CiteScore

1.60

自引率

70.40%

发文量

434

审稿时长

2 months

期刊介绍： Neurology India (ISSN 0028-3886) is Bi-monthly publication of Neurological Society of India. Neurology India, the show window of the progress of Neurological Sciences in India, has successfully completed 50 years of publication in the year 2002. ‘Neurology India’, along with the Neurological Society of India, has grown stronger with the passing of every year. The full articles of the journal are now available on internet with more than 20000 visitors in a month and the journal is indexed in MEDLINE and Index Medicus, Current Contents, Neuroscience Citation Index and EMBASE in addition to 10 other indexing avenues. This specialty journal reaches to about 2000 neurologists, neurosurgeons, neuro-psychiatrists, and others working in the fields of neurology.