Clinical utility of swept-source optical coherence tomography angiography for the diagnosis of exudative maculopathy.

IF 2.1 3区医学 Q2 OPHTHALMOLOGY

Japanese Journal of Ophthalmology Pub Date : 2024-08-31 DOI:10.1007/s10384-024-01115-w

Ai Fujita Sajiki, Keiko Kataoka, Jun Takeuchi, Hikaru Ota, Yuyako Nakano, Etsuyo Horiguchi, Hiroki Kaneko, Hiroko Terasaki, Yasuki Ito, Koji M Nishiguchi

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引用次数: 0

Abstract

Purpose: To assess the feasibility of swept-source optical coherence tomography angiography (SS-OCTA) to differentiate macular diseases, including nonpolypoidal macular neovascularization (MNV), polypoidal choroidal vasculopathy (PCV), type 3 MNV, and chronic central serous chorioretinopathy (CSC) without indocyanine green angiography (ICGA).

Study design: Retrospective observational study.

Methods: This study examined 63 eyes of 63 patients with treatment-naive neovascular age-related macular degeneration (AMD), including 23 eyes with nonpolypoidal MNV, 17 eyes with PCV, and 1 eye with type 3 MNV and 22 eyes with chronic CSC. Two independent retina specialists, blinded to the clinical diagnosis, assessed each case of neovascular AMD and chronic CSC using only B-scan and en face images of SS-OCTA without referring to other examination outcomes.

Results: By SS-OCTA alone, 19 eyes were diagnosed with nonpolypoidal MNV, 17 eyes with PCV, 2 eyes with type 3 MNV, and 22 eyes with chronic CSC, indicating high sensitivity (82.6%, 94.1%, 100%, and 100%, respectively) and specificity (100%, 97.8%, 98.4%, and 100%, respectively); however, three eyes could not be diagnosed because of obscure images. The agreement of diagnosis with SS-OCTA alone was high between the two specialists (κ = 0.82).

Conclusion: SS-OCTA showed high sensitivity and specificity in the differentiation of nonpolypoidal MNV, PCV, type 3 MNV, and chronic CSC. The differential criteria based on SS-OCTA could be a substitute for the ICGA-based diagnoses.

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扫源光学相干断层血管造影在诊断渗出性黄斑病变中的临床实用性。

目的：评估扫源光学相干断层血管造影（SS-OCTA）区分黄斑疾病（包括非息肉状黄斑新生血管（MNV）、息肉状脉络膜血管病（PCV）、3型MNV和慢性中心性浆液性脉络膜视网膜病变（CSC））的可行性，而无需吲哚青绿血管造影（ICGA）：研究设计：回顾性观察研究：本研究对 63 名未经治疗的新生血管性年龄相关性黄斑变性（AMD）患者的 63 只眼睛进行了检查，其中包括 23 只患有非息肉状新生血管性黄斑变性的眼睛、17 只患有 PCV 的眼睛、1 只患有 3 型新生血管性黄斑变性的眼睛以及 22 只患有慢性 CSC 的眼睛。两名独立的视网膜专家在临床诊断盲法的基础上，仅使用 SS-OCTA 的 B 扫描图像和正面图像对每例新生血管性 AMD 和慢性 CSC 进行评估，而不参考其他检查结果：仅通过 SS-OCTA，19 只眼睛被诊断为非息肉型 MNV，17 只眼睛被诊断为 PCV，2 只眼睛被诊断为 3 型 MNV，22 只眼睛被诊断为慢性 CSC，显示出较高的灵敏度（分别为 82.6%、94.1%、100% 和 100%）和特异性（分别为 100%、97.8%、98.4% 和 100%）；但是，有 3 只眼睛因图像模糊而无法诊断。两位专家仅凭 SS-OCTA 诊断的一致性很高（κ = 0.82）：结论：SS-OCTA 在鉴别非息肉型 MNV、PCV、3 型 MNV 和慢性 CSC 方面显示出较高的灵敏度和特异性。基于 SS-OCTA 的鉴别标准可替代基于 ICGA 的诊断。

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来源期刊

Japanese Journal of Ophthalmology 医学-眼科学

CiteScore

4.80

自引率

8.30%

发文量

审稿时长

6-12 weeks

期刊介绍： The Japanese Journal of Ophthalmology (JJO) was inaugurated in 1957 as a quarterly journal published in English by the Ophthalmology Department of the University of Tokyo, with the aim of disseminating the achievements of Japanese ophthalmologists worldwide. JJO remains the only Japanese ophthalmology journal published in English. In 1997, the Japanese Ophthalmological Society assumed the responsibility for publishing the Japanese Journal of Ophthalmology as its official English-language publication. Currently the journal is published bimonthly and accepts papers from authors worldwide. JJO has become an international interdisciplinary forum for the publication of basic science and clinical research papers.