Regulation of dermal circadian pathways by a novel topical formulation.

IF 2.7 4区医学 Q2 DERMATOLOGY

International Journal of Cosmetic Science Pub Date : 2024-09-01 DOI:10.1111/ics.13017

Charlene DeHaven, Stephanie Wheeler, Anna Langerveld, C Bryan Johns

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引用次数: 0

Abstract

Skin health is impacted by a wide range of intrinsic and extrinsic factors (J Dermatol Sci, 2017, 85, 152), including those that impact circadian rhythm, such as sleep disruption (Textbook of Aging Skin, 2016), UV (Biomed Aging Pathol, 2013, 3, 161) and blue light (Int J Cosmet Sci, 2019, 41, 558). Disruption of the skin's endogenous circadian balance, even by a consistently late bedtime, has deleterious effects on multiple measurements of skin health, including hydration, skin barrier protection, microbiome counts and skin regeneration, among others (Clin Cosmet Investig Dermatol, 2022, 15, 1051). Skin repair processes occur at night and help to maintain important aspects of skin health (FEBS Lett, 2021, 595, 2413). Interest is increasing in the development of topical products that help restore proper circadian function. This study demonstrates that a proprietary topical formulation regulates new and established gene and protein biomarkers of circadian entrainment and circadian rhythm, demonstrating the product's potential to maintain appropriate dermal diurnal balance.

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一种新型外用制剂对皮肤昼夜节律途径的调节。

皮肤健康受到多种内在和外在因素的影响（J Dermatol Sci，2017，85，152），包括影响昼夜节律的因素，如睡眠中断（《皮肤老化教科书》，2016）、紫外线（《生物医学老化病理学》，2013，3，161）和蓝光（《国际美容科学》，2019，41，558）。破坏皮肤的内源性昼夜节律平衡，即使是持续晚睡，也会对皮肤健康的多项指标产生有害影响，包括水合作用、皮肤屏障保护、微生物群数量和皮肤再生等（Clin Cosmet Investig Dermatol，2022，15，1051）。皮肤修复过程发生在夜间，有助于维持皮肤健康的重要方面（FEBS Lett，2021，595，2413）。人们对开发有助于恢复正常昼夜节律功能的外用产品越来越感兴趣。这项研究表明，一种专有的外用配方可以调节昼夜节律和昼夜交替的新的和已确定的基因和蛋白质生物标志物，证明该产品具有维持皮肤适当昼夜平衡的潜力。

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来源期刊

International Journal of Cosmetic Science DERMATOLOGY-

CiteScore

4.60

自引率

4.30%

发文量

期刊介绍： The Journal publishes original refereed papers, review papers and correspondence in the fields of cosmetic research. It is read by practising cosmetic scientists and dermatologists, as well as specialists in more diverse disciplines that are developing new products which contact the skin, hair, nails or mucous membranes. The aim of the Journal is to present current scientific research, both pure and applied, in: cosmetics, toiletries, perfumery and allied fields. Areas that are of particular interest include: studies in skin physiology and interactions with cosmetic ingredients, innovation in claim substantiation methods (in silico, in vitro, ex vivo, in vivo), human and in vitro safety testing of cosmetic ingredients and products, physical chemistry and technology of emulsion and dispersed systems, theory and application of surfactants, new developments in olfactive research, aerosol technology and selected aspects of analytical chemistry.