Antimicrobial susceptibility of commensal Neisseria spp. in parents and their children in Belgium: a cross-sectional survey.

IF 2.2 4区生物学 Q3 MICROBIOLOGY

Fems Microbiology Letters Pub Date : 2024-01-09 DOI:10.1093/femsle/fnae069

Saïd Abdellati, Zina Gestels, Jolein Gyonne Elise Laumen, Christophe Van Dijck, Irith De Baetselier, Tessa de Block, Dorien Van den Bossche, Thibaut Vanbaelen, Izumo Kanesaka, Sheeba Santhini Manoharan-Basil, Chris Kenyon

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引用次数: 0

Abstract

Background: commensal Neisseria species are part of the oropharyngeal microbiome and play an important role in nitrate reduction and protecting against colonization by pathogenic bacteria. They do, however, also serve as a reservoir of antimicrobial resistance. Little is known about the prevalence of these species in the general population, how this varies by age and how antimicrobial susceptibility varies between species.

Methods: we assessed the prevalence and antimicrobial susceptibility of commensal Neisseria species in the parents (n = 38) and children (n = 50) of 35 families in Belgium.

Results: various commensal Neisseria (n = 5) could be isolated from the participants. Most abundant were N. subflava and N. mucosa. Neisseria subflava was detected in 77 of 88 (87.5%) individuals and N. mucosa in 64 of 88 (72.7%). Neisseria mucosa was more prevalent in children [41/50 (82%)] than parents [23/38 (60.5%); P < .05], while N. bacilliformis was more prevalent in parents [7/36 (19.4%)] than children [2/50 (4%); P < .05]. Neisseria bacilliformis had high ceftriaxone minimum inhibitory concentrations (MICs; median MIC 0.5 mg/l; IQR 0.38-0.75). The ceftriaxone MICs of all Neisseria isolates were higher in the parents than in the children. This could be explained by a higher prevalence of N. bacilliformis in the parents.

Interpretation: the N. bacilliformis isolates had uniformly high ceftriaxone MICs which warrant further investigation.

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比利时父母及其子女对共生奈瑟氏菌属的抗菌药敏感性：横断面调查。

背景：共生奈瑟氏菌是口咽部微生物组的一部分，在硝酸盐还原和防止病原菌定植方面发挥着重要作用。然而，它们也是抗菌药耐药性的储存库。我们对这些物种在普通人群中的流行率、不同年龄段的流行率差异以及不同物种对抗菌药的敏感性差异知之甚少：方法：我们对比利时 35 个家庭的父母（38 人）和儿童（50 人）中共生奈瑟菌的流行率和抗菌药敏感性进行了评估：结果：可从参与者身上分离出各种共生奈瑟菌（n = 5）。最多的是亚弗拉伐奈瑟菌和粘膜奈瑟菌。88 人中有 77 人（87.5%）检测到亚弗拉伐奈瑟菌，88 人中有 64 人（72.7%）检测到粘膜奈瑟菌。儿童（41/50 [82%]）比父母（23/38 [60.5%]；P 解释：N.杆菌分离株的头孢曲松 MIC 值都很高，值得进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Fems Microbiology Letters 生物-微生物学

CiteScore

4.30

自引率

0.00%

发文量

112

审稿时长

1.9 months

期刊介绍： FEMS Microbiology Letters gives priority to concise papers that merit rapid publication by virtue of their originality, general interest and contribution to new developments in microbiology. All aspects of microbiology, including virology, are covered. 2019 Impact Factor: 1.987, Journal Citation Reports (Source Clarivate, 2020) Ranking: 98/135 (Microbiology) The journal is divided into eight Sections: Physiology and Biochemistry (including genetics, molecular biology and ‘omic’ studies) Food Microbiology (from food production and biotechnology to spoilage and food borne pathogens) Biotechnology and Synthetic Biology Pathogens and Pathogenicity (including medical, veterinary, plant and insect pathogens – particularly those relating to food security – with the exception of viruses) Environmental Microbiology (including ecophysiology, ecogenomics and meta-omic studies) Virology (viruses infecting any organism, including Bacteria and Archaea) Taxonomy and Systematics (for publication of novel taxa, taxonomic reclassifications and reviews of a taxonomic nature) Professional Development (including education, training, CPD, research assessment frameworks, research and publication metrics, best-practice, careers and history of microbiology) If you are unsure which Section is most appropriate for your manuscript, for example in the case of transdisciplinary studies, we recommend that you contact the Editor-In-Chief by email prior to submission. Our scope includes any type of microorganism - all members of the Bacteria and the Archaea and microbial members of the Eukarya (yeasts, filamentous fungi, microbial algae, protozoa, oomycetes, myxomycetes, etc.) as well as all viruses.