The platelet-mitochondria nexus in autoimmune and musculoskeletal diseases

IF 4.5 3区 医学 Q2 IMMUNOLOGY
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引用次数: 0

Abstract

Platelets are crucial for thrombosis and hemostasis. Importantly, they contain mitochondria that are responsible for energy generation and therefore vital for platelet survival and activation. Activated platelets can release mitochondria that may be free or encapsulated in platelet extracellular vesicles (EVs). Extruded mitochondria are a well-known source of mitochondrial DNA, and mitochondrial antigens that can be targeted by autoantibodies forming immune complexes (IC). Interaction of IC with the platelet cell surface FcγRIIA receptor results in platelet activation and release of platelet granule components. In this review, we summarize how platelets and mitochondria may contribute to the pathogenesis of different autoimmune and musculoskeletal diseases. Targeting key drivers of mitochondrial extrusion may ultimately lead to urgently needed targeted pharmacological interventions for treating inflammation and thrombotic diathesis, and halting organ damage in some of these rheumatological conditions.

自身免疫性疾病和肌肉骨骼疾病中的血小板-线粒体关系。
血小板对血栓形成和止血至关重要。重要的是,它们含有负责产生能量的线粒体,因此对血小板的存活和活化至关重要。活化的血小板可释放线粒体,这些线粒体可能是游离的,也可能包裹在血小板胞外囊泡(EVs)中。众所周知,挤出的线粒体是线粒体 DNA 和线粒体抗原的来源,这些抗原可被形成免疫复合物(IC)的自身抗体靶向。IC 与血小板细胞表面的 FcγRIIA 受体相互作用,导致血小板活化并释放血小板颗粒成分。在这篇综述中,我们总结了血小板和线粒体如何可能导致不同的自身免疫性疾病和肌肉骨骼疾病的发病机制。针对线粒体挤压的关键驱动因素可能最终导致急需的靶向药物干预,以治疗炎症和血栓形成,并阻止其中一些风湿病的器官损伤。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Clinical immunology
Clinical immunology 医学-免疫学
CiteScore
12.30
自引率
1.20%
发文量
212
审稿时长
34 days
期刊介绍: Clinical Immunology publishes original research delving into the molecular and cellular foundations of immunological diseases. Additionally, the journal includes reviews covering timely subjects in basic immunology, along with case reports and letters to the editor.
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