IL-17 in skin infections and homeostasis

IF 4.5 3区 医学 Q2 IMMUNOLOGY
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Abstract

Interleukin (IL) 17 is a proinflammatory cytokine belonging to a structurally related group of cytokines known as the IL-17 family. It has been profoundly studied for its contribution to the pathology of autoimmune diseases. However, it also plays an important role in homeostasis and the defense against extracellular bacteria and fungi. IL-17 is important for epithelial barriers, including the skin, where some of its cellular targets reside. Most of the research work on IL-17 has focused on its effects in the skin within the context of autoimmune diseases or sterile inflammation, despite also having impact on other skin conditions. In recent years, studies on the role of IL-17 in the defense against skin pathogens and in the maintenance of skin homeostasis mediated by the microbiota have grown in importance. Here we review and discuss the cumulative evidence regarding the main contribution of IL-17 in the maintenance of skin integrity as well as its protective or pathogenic effects during some skin infections.

皮肤感染和稳态中的 Il-17。
白细胞介素(IL)17 是一种促炎细胞因子,属于一组结构相关的细胞因子,被称为 IL-17 家族。人们对它在自身免疫性疾病病理学中的作用进行了深入研究。不过,它在体内平衡以及抵御细胞外细菌和真菌方面也发挥着重要作用。IL-17 对包括皮肤在内的上皮屏障非常重要,它的一些细胞靶点就位于皮肤上。尽管 IL-17 对其他皮肤病也有影响,但大多数有关 IL-17 的研究都集中在它对自身免疫性疾病或无菌性炎症皮肤的影响上。近年来,有关 IL-17 在防御皮肤病原体和维持由微生物群介导的皮肤稳态中的作用的研究越来越重要。在此,我们回顾并讨论了有关 IL-17 在维护皮肤完整性方面的主要贡献及其在某些皮肤感染中的保护或致病作用的累积证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Clinical immunology
Clinical immunology 医学-免疫学
CiteScore
12.30
自引率
1.20%
发文量
212
审稿时长
34 days
期刊介绍: Clinical Immunology publishes original research delving into the molecular and cellular foundations of immunological diseases. Additionally, the journal includes reviews covering timely subjects in basic immunology, along with case reports and letters to the editor.
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